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Immunology

Image: The Clusterin Human ELISA kit (Photo courtesy of Invitrogen).

Blood Biomarkers Help Diagnose Parkinson's Disease

The identification of circulating biomarkers that closely correlate with Parkinson’s disease (PD) has failed several times in the past. A conventional pipeline for biomarker discovery usually contemplates the collection of clinical samples, such as blood, and their analysis by mass spectrometry. More...
05 May 2020
Image: Schematic Diagram of the Molecular Analysis of Clinically Defined Subsets of High-Grade Serous Ovarian Cancer (Photo courtesy of MD Anderson Cancer Center).

Molecular Differences Discovered Among Ovarian Cancer Subgroups

Ovarian cancer is a highly diverse disease with a high rate of overall mortality. High-grade serous ovarian cancer (HGSC) is the most common and aggressive type of epithelial ovarian cancer, exhibiting high levels of tumor heterogeneity and variable clinical outcomes. More...
28 Apr 2020
Image: The PHOMO Microplate Reader: the sophisticated optical design combined with the accurate plate transport system allows for high resolution scanning (29 points per well) to support agglutination assays (Photo courtesy of Autobio Diagnostics Co).

Urea Dissociation Tests Reduces SARS-CoV-2 IgM False-Positives

At present, the diagnosis of COVID-19 is mainly based on epidemiological history inquiry, laboratory testing, and chest radiology examination. Among these examinations, the detection of nucleic acid from SARS-CoV-2 is the direct evidence for COVID-19 diagnosis. More...
28 Apr 2020
Image: Diversity of peripheral blood human NK cells identified by single-cell RNA sequencing (Photo courtesy of University of Manchester).

Human NK Cells Identified by Single-Cell RNA Sequencing

Natural killer (NK) cells are cytotoxic lymphocytes that are crucial for viral defense as well as detecting and killing cancer cells. This cell type is therefore of great interest for cancer immunotherapy. More...
27 Apr 2020
Image: Histology of multinucleated giant cells engulfing calcium oxalate crystals from a patient with type 1 primary hyperoxaluria (Photo courtesy of Jonathan E. Zuckerman, MD, PhD).

Biomarker Panel Evaluated for Primary Hyperoxaluria Patients

Primary hyperoxaluria (PH) is a group of autosomal recessive disorders characterized by recurrent urinary stones and nephrocalcinosis. Roughly half of PH patients present with advanced chronic kidney disease (CKD) at the time of diagnosis. More...
27 Apr 2020
Image: The Lymphoprep Tube is a sterile tube in that contains the Lymphoprep (separation medium) under a plastic filter disc. This is a simple and effective protocol most commonly used to isolate mononuclear cells (PBMCs) from human blood (Photo courtesy of Axis-Shield).

Functional Comparison of Different Tubes for Isolating Mononuclear Cells

Profiling of immune cells with single-cell technologies is a key component of both basic science studies, evaluation of therapeutics in clinical trials, and clinical care. Cryopreserved human peripheral blood mononuclear cells (PBMCs) are a commonly used sample type for a variety of immunological assays. More...
23 Apr 2020
Image: Mass cytometry with Helios uses CyTOF technology to enable deep profiling of translational and clinical samples across a range of cell surface and intracellular markers (Photo courtesy of Fluidigm).

Missing BAP1 Gene Associated with Immunosuppressive Molecules in Uveal Melanoma

Uveal melanoma is a cancer (melanoma) of the eye involving the iris, ciliary body, or choroid (collectively referred to as the uvea). Tumors arise from the pigment cells (melanocytes) that reside within the uvea and give color to the eye. More...
22 Apr 2020
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The Immunology channel of LabMedica deals with diagnostic techniques and immuonassays such as ELISA, pregnancy tests, immunoblotting, immunohistochemical staining, serology, and associated hardware.

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