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Immunology

Image: The Hyperion Imaging System brings proven CyTOF technology together with imaging capability to empower simultaneous interrogation of four to 37 protein markers using Imaging Mass Cytometry (Photo courtesy of Fluidigm).

Imaging Mass Cytometry Uncovers Novel Breast Cancer Subgroups

 Changing the course of how diseases are treated and ultimately cured requires a comprehensive understanding of complex cellular phenotypes and their interrelationships in the spatial context of the tissue microenvironment. More...
03 Feb 2020
Image: The BD FACSVerse Flow Cytometer (Photo courtesy of BD Biosciences).

Immune Profiles Analyzed in Acute Myeloid Leukemia Bone Marrow

 In acute myeloid leukemia (AML), myeloid lineage precursor cells modified by somatic mutations and transcriptomic dysregulation infiltrate the bone marrow (BM) and disrupt normal hematopoiesis. More...
03 Feb 2020
Image: The Sebia Hydragel 18 Apo E Isofocusing showing different apoE isoforms from 16 patients tested. The “control serum” provided in the Sebia kit is included in each series, together with two already typed serum samples as internal controls (as an example, E3/E2 and E4/E4) (Photo courtesy of Sorbonne University).

Semi-Automatic Isoelectric Focusing Evaluated for Apolipoprotein E Phenotyping

 Plasma apolipoprotein E (apoE) mainly arises from liver hepatocytes (75%), but the brain (astrocytes, oligodendrocytes, microglia, astrocytes) also synthesizes apoE found in the cerebrospinal fluid. More...
30 Jan 2020
Image: Blood smear of patient with intracellular cocci in pairs inside a white blood cell, possibly indicating sepsis. Oncostatin-M is a biomarker for sepsis risk (Photo courtesy of Dr. Wim van der Meer).

Biomarker Identifies Septic Patients at Higher Risk for Mortality

 Sepsis is a life-threatening condition that arises when the body's response to infection causes injury to its own tissues and organs. Common signs and symptoms include fever, increased heart rate, increased breathing rate, and confusion. More...
28 Jan 2020
Image: The BD Bactec FX40: the blood culturing instruments used with patented resin-containing media have shown higher rates of organism recovery, allowing for proper diagnosis and treatment of bloodstream infections (Photo courtesy of Becton, Dickinson and Company).

CSF Cytokine Characteristics Defined from Children with Meningitis

 Enteroviral meningitis (EVM) are the most common etiological agent for viral encephalitis, and are predominantly reported among children and always present as a milder clinical illness than other infectious causes which only need supportive therapy. More...
21 Jan 2020
Image: Histopathology of Leptomeningeal Melanoma Metastases: tumor cell clusters in the subarachnoid space in a brain biopsy (Photo courtesy of selbst).

Molecular Characteristics of Leptomeningeal Melanoma Metastases Identified

 Patients with advanced melanoma who develop metastases in the leptomeninges, the fluid filled membranes surrounding the brain and spinal cord, have an extremely poor prognosis. Most patients only survive for eight to 10 weeks after diagnosis. More...
20 Jan 2020
Image: The Attune NxT Acoustic Focusing Cytometer is ideal for immunophenotyping and signaling studies, cell cycle analysis, detection of rare events, stem cell analysis, cancer and apoptosis studies, microbiological assays, and more (Photo courtesy of Thermo Fisher Scientific)

Diagnostic Assay Identifies Leukemic Stem Cells

 Acute myeloid leukemia (AML) is the most common type of leukemia in adults. It is characterized by the pathological expansion of immature cells (myeloblasts) that invade the bone marrow and expand into the blood, affecting the production of the rest of the healthy cells. More...
15 Jan 2020
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The Immunology channel of LabMedica deals with diagnostic techniques and immuonassays such as ELISA, pregnancy tests, immunoblotting, immunohistochemical staining, serology, and associated hardware.

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