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Immunology

Image: The PLATELIA ASPERGILLUS Ag Test (Photo courtesy of Bio-Rad Laboratories).

Invasive Pulmonary Aspergillosis Diagnosed by Molecular Test

Invasive aspergillosis (IA) is a common opportunistic fungal infection, mainly affecting patients with severe and prolonged neutropenia. Early diagnosis of invasive pulmonary aspergillosis (IPA) is notoriously difficult, but crucial for prompt treatment initiation required to improve patient outcome. More...
12 Jun 2019
Image: A typical human serum mannose-binding lectin enzyme-linked immunoassay kit (Photo courtesy of Hycult Biotech).

Mannose-Binding Lectin Associated with IgG Subclass Deficiency

Mannose-binding lectin (MBL; mannan-binding protein or lectin) is involved in innate immune defense, is produced largely by hepatocytes and is encoded by MBL2 (chromosome 10q21.1). MBL promotes killing of microorganisms by complement activation via the lectin pathway and by opsonization. More...
11 Jun 2019
Image: The unique pipette tip created with a 3D printer to perform enzyme-linked immunosorbent assays (Photo courtesy of the University of Connecticut).

Novel 3D-Printed Technology Lowers Cost of ELISA

Traditional enzyme-linked immunosorbent assay (ELISA) tests are performed on plates featuring 96 micro-wells; each well works as a separate testing chamber where samples can be combined with various agents that will then react with the sample, typically by changing color. More...
06 Jun 2019
Image: Serum Cyr61 concentrations and diagnostic performance of Cyr61 in participants in the training cohort. A: Levels of serum Cyr61 in healthy controls and RA patients (Photo courtesy of Peking University First Hospital).

Cysteine-Rich 61 Biomarker Reflects RA Disease Activity

Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease that causes progressive articular damage, functional loss, and comorbidity. Until now, the exact pathological processes involved in RA remain incompletely understood. More...
05 Jun 2019
Image: The RX Daytona chemistry analyzer is a compact fully automated benchtop clinical chemistry analyzer perfect for small to medium throughput laboratories (Photo courtesy of Randox Laboratories).

Urinary Biomarkers Diagnose Serious Kidney Allergic Reaction

Acute interstitial nephritis is a condition marked by inflammation and swelling of the renal tubules, the tiny portals in the kidneys where blood is filtered. As a result, the tubules cannot properly reabsorb water and useful organic substances, such as glucose and amino acids, or secrete waste products such as urea and creatinine into urine. More...
27 May 2019
Image: The V-PLEX Aβ Peptide Panel 1 (6E10) Kit (Photo courtesy of Meso Scale Discovery).

Diagnostic Process Detects Alzheimer’s Years before Symptoms Appear

Alzheimer's disease (AD) pathology is accompanied by misfolding of amyloid-β (Aβ) and tau from monomeric into β-sheet–enriched pathogenic species. This process is suggested to precede about 10 to 15 years before clinical onset of the disease. More...
23 May 2019
Image: A digitally colorized, transmission electron microscopic (TEM) image, which reveals some of the ultrastructural morphology displayed by an Ebola virus virion (Photo courtesy of Cynthia Goldsmith / CDC).

Simple and Inexpensive Ebola Virus Disease Test Developed

Ebola and Marburg viruses can cause severe bleeding and organ failure, with fatality rates reaching 90% in some outbreaks. The diseases spread through direct contact with bodily fluids of an infected person, monkey, gorilla, chimpanzee or bat. More...
21 May 2019
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The Immunology channel of LabMedica deals with diagnostic techniques and immuonassays such as ELISA, pregnancy tests, immunoblotting, immunohistochemical staining, serology, and associated hardware.

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