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Immunology

Image: The MAGPIX CCD Imager, a compact multiplexing unit (Photo courtesy of Luminex).

Malarial Cytokine Responses Reduced by Age in Exposed Children

Elevated levels of pro-inflammatory cytokines and chemokines in the peripheral blood during acute malaria infection contribute to the control of parasitemia, but are also responsible for much of the immunopathology seen during symptomatic disease. More...
10 Jan 2018
Image: The SimulToF matrix assisted laser desorption/ionization time of flight mass spectrometer (Photo courtesy of Virgin Instruments).

Protein Signature Associated with Outcome in Metastatic Melanoma

Clinical results in metastatic melanoma with the antibodies nivolumab and pembrolizumab to anti– programmed cell death protein 1 (PD-1) have led to clinically and statistically significant improvements in progression-free and overall survival compared to alternative first- and second-line therapies. More...
10 Jan 2018
Image: The BOND-MAX fully automated immunohistochemical (IHC) and in situ hybridization (ISH) stainer (Photo courtesy of Leica Biosystems).

Prognostic Biomarker Found for Endometrial Cancer

Endometrial cancer (EC) is a major health concern due to its rising incidence. Whilst early stage disease is generally cured by surgery, advanced EC has a poor prognosis with limited treatment options, and altered energy metabolism is a hallmark of malignancy. More...
08 Jan 2018
Image: The Bio-Plex 200 is a suspension multiplexing array fluorescence reader used for multiplex assays that allows to measure up to 100 biomolecule of protein or nucleic acid in a single sample (Photo courtesy of Bio-Rad Laboratories).

Accurate Tool Developed to Track New HIV Infections

An effort is underway to develop a more accurate way to gauge the incidence of human immunodeficiency virus (HIV) infections in large populations, which will improve scientific studies and prevention strategies worldwide. More...
04 Jan 2018
Image: The Abbott m2000 RealTime System is a highly flexible and proven solution featuring a broad menu of in vitro diagnostic assays (Photo courtesy of Abbott Molecular Diagnostics).

Molecular Automation Is Changing Clinical Laboratories

Most mid-career laboratory medicine professionals find it hard not to recall the days when DNA had to be extracted manually and polyacrylamide gels were mixed by hand without also reflecting on how fast things have changed. More...
02 Jan 2018
Image: Isoelectric focusing on agarose gel for immunoglobulins: a) Original scanned color image, b) gray scale image (Photo courtesy of the Catholic University of Lille).

Images Evaluated for CSF Electrophoresis of IgG Bands

Multiple sclerosis (MS) involves inflammatory lesions of white matter in the central nervous system (CNS) that spread over time. In MS immune reactions lead to intrathecal synthesis of specific immunoglobulins (IgGs) that can be detected in biological fluid samples both quantitatively and qualitatively by isoelectric focusing of supplementary oligoclonal IgG bands. More...
02 Jan 2018
Image: A diagram depicting high internal/external surface area ratio and binding capacity of nanocages. Affinity ligands covalently immobilized in the inner volume establish high-affinity noncovalent interaction with tuberculosis (TB) antigens (Photo courtesy of George Mason University).

Urine Test Developed for Accurate TB Detection

An accurate screening test for active pulmonary tuberculosis (TB) is urgently needed for patients who are not co-infected with human immunodeficiency virus (HIV). Worldwide, TB is one of the most prevalent bacterial infections, with the highest mortality in developing countries. More...
28 Dec 2017
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The Immunology channel of LabMedica deals with diagnostic techniques and immuonassays such as ELISA, pregnancy tests, immunoblotting, immunohistochemical staining, serology, and associated hardware.

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