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Immunology

Image: A micrograph of eosinophilic esophagitis (EoE), H&E stain. Characteristic features are present: Abundant eosinophils – criteria vary; one common definition is: > 20 eosinophils/0.24 mm2; Papillae are elongated; papillae reach into the top 1/3 of the epithelial layer; Basal cell hyperplasia; > 3 cells thick or >15% of epithelial thickness; Spongiosis (Photo courtesy of Michael Bonert / Wikimedia).

Potential Noninvasive Biomarker of EoE Disease Activity Identified

Researchers have identified a potential blood-based marker of disease activity for the severe and often painful food allergic disease eosinophilic esophagitis (EoE) – possibly leading to a blood test, which could spare EoE patients, often children, the discomfort and risk of the currently used invasive endoscopic monitoring procedures. More...
24 May 2016
Image: Adult deer tick Ixodes scapularis. Lyme disease is caused by Borrelia bacteria and transmitted to humans upon the bite of infected ticks of the genus Ixodes (Photo courtesy of Scott Bauer, Agricultural Research Service of United States Department of Agriculture).

Differentiating Septic Arthritis from Lyme Disease Arthritis in Children’s Knees

The two conditions often include similar symptoms and both can show elevated measurements in laboratory tests for inflammation and for white blood cell (WBC) counts – however each condition requires different immediate treatment. A new study identifies symptoms that are predictive of septic arthritis when the condition presents itself in a child’s knee – an important distinction in areas where Lyme disease is endemic. More...
24 May 2016
Image: On-bead magnetic screening for autism spectrum disorder blood biomarkers (Photo courtesy of UT Southwestern Medical Center).

Novel Blood Biomarker Identified for Autism

Early intervention is the key to the best treatment for autism spectrum disorder (ASD), which affects about 1 in 70 children. Unfortunately, most children are not diagnosed until about age four, when communication and social disabilities become apparent. More...
17 May 2016

Study Finds Excessive Testing Prescribed for Monoclonal Gammopathy Patients

A retrospective analysis has determined that the tests for M-protein that physicians routinely order to help diagnose and monitor patients with the age-related immune disorder monoclonal gammopathy (MG), often do not benefit the patient. Pathologists who performed the study have proposed an optimizing algorithm for more effective decision-making based on the evidence for clinical value. More...
17 May 2016
Image: A dark field photomicrography reveals the presence of spirochete, or “corkscrew-shaped” bacteria known as Borrelia spp., which is the pathogen responsible for causing Lyme disease (Photo courtesy of Jeffrey Nelson).

New Test Developed For Early Detection Of Lyme Disease

A new test for early detection of Lyme disease (borreliosis) is being developed and this will improve the ability to detect an active infection more easily than before so that healthy people with Lyme disease antibodies in their blood do not receive unnecessary antibiotic treatment and so that appropriate treatments can be initiated at an early stage. More...
12 May 2016
Image: The MRX microplate reader (Photo courtesy of Dynatech Medical Products).

Blood Test Detects Breast Cancer Spread Earlier

More sensitive, non-invasive tests are required for secondary breast cancer, which occurs when new tumors grow in the bone, liver, lung or brain, to make diagnosis easier and for treatment to begin as early as possible. More...
12 May 2016
Image: A diagram of the NuQ biomarker assay for prostate cancer (Photo courtesy of VolitionRx).

Blood Biomarker Assay Detects Prostate Cancer Early

Approximately 14% of men will be diagnosed with prostate cancer at some point during their lifetime and nearly three million men are estimated to be living with prostate cancer in the USA alone. More...
12 May 2016
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The Immunology channel of LabMedica deals with diagnostic techniques and immuonassays such as ELISA, pregnancy tests, immunoblotting, immunohistochemical staining, serology, and associated hardware.

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