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Microbiology

Image: The UF-500i fully automated urine particle analyzer (Photo courtesy of Sysmex Corporation).

Flow Cytometry Employed in Diagnosing Male Urethritis

According to the established guidelines, diagnosis of non-gonococcal urethritis should be confirmed by demonstrating polymorphonuclear leukocytes from the anterior urethra using a Gram-stained (GSS) or methylene blue-stained urethral smear. More...
17 Dec 2020
Image: TriSilix is a tiny new silicon-based lab-on-chip test that could pave the way for cheap handheld infectious disease testing (Photo courtesy of Imperial College London).

Lab-on-a-Chip Infection Test Provides Cheaper, Faster Portable Diagnostics

Rapid screening and low-cost diagnosis play a crucial role in choosing the correct course of intervention when dealing with highly infectious pathogens. This is especially important if the disease-causing agent has no effective treatment. More...
15 Dec 2020
Image: Microscopic field of view showing the detection of P. falciparum parasites in DAPI-stained thin smears: (1) infected red blood cells (RBCs), (2) normal RBCs, (3) leukocytes and (4) fluorescent debris (Photo courtesy of University of Helsinki).

Deep Learning Digital Microscope Scanner Detects Malaria

Malaria remains a major global health problem with a need for improved field-usable diagnostic tests. Light microscopy assessment of blood smears to detect Plasmodium parasites remains the diagnostic gold standard and allows detection and quantification of Plasmodium species while also being more sensitive than rapid diagnostic tests (RDTs). More...
09 Dec 2020
Image: Appearance of a `false brush border` of Brachyspira pilosicoli cells attached by one cell end to the luminal surface of human colonic enterocytes in a patient diagnosed with human intestinal spirochetosis (Photo courtesy of David J. Hampson, PhD, DSc).

Specific Gut Bacterium Linked to Irritable Bowel Syndrome

The incidence of Irritable Bowel Syndrome (IBS) steeply increases following a gastroenteritis episode, suggesting a possible causative role for microbial perturbation. Gut microbiota composition studies overwhelmingly rely on fecal material. More...
08 Dec 2020
Image: The Cytek Aurora spectral flow cytometer (Photo courtesy of Cytek Bioscience).

Distinct Inflammatory Profiles Distinguish COVID-19 From Influenza

Acute respiratory failure occurs in a subset of COVID-19 patients. Understanding the etiology of respiratory failure in COVID-19 patients is critical for determining the best management strategies and pharmacologic targets for treatment. More...
30 Nov 2020
Image: Lung cells infected with coronavirus (Photo courtesy of The Hebrew University of Jerusalem).

SARS-CoV-2 RNA Test Assessed Among Recovered COVID-19 Patients

Some patients who have recovered from coronavirus disease 2019 (COVID-19) with documented negative real-time polymerase chain reaction (RT-PCR) results at the time of recovery have had subsequent positive RT-PCR test results for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). More...
25 Nov 2020
Image: The portable MinION sequencing platform runs one flow cell and desktop GridION can run up to five flow cells at any time (Photo courtesy of Oxford Nanopore).

Metagenomic Sequencing Quickly Identifies Pathogens in Body Fluids

Metagenomic next-generation sequencing (mNGS) is a shotgun sequencing approach in which all of the nucleic acid (DNA and RNA) in a clinical sample is sequenced at a very high depth, 10-20 million sequences per sample. More...
23 Nov 2020
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The LabMedica Microbiology channel provides the latest news in the fields of epidemiology, bacteriology, virology, and parasitology, all viewed from the unique perspective of Laboratory Medicine.

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