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Pathology

Image: Histological photomicrograph of a colonic biopsy showing a crypt abscess, a classic finding in ulcerative colitis (Photo courtesy of KGH).

Important Genetic Mechanism Behind Inflammatory Bowel Disease Revealed

The two main forms of Inflammatory Bowel Disease (IBD), Crohn's disease and ulcerative colitis, have an important genetic component. More than 240 genetic regions have been identified that associate with IBD, more than any other pathological condition that has been studied. More...
23 Apr 2020
Image: The CELLSEARCH System is the first and only clinically validated, FDA-cleared system for identification, isolation, and enumeration of circulating tumor cells (CTCs) from a simple blood test (Photo courtesy of Menarini Silicon Biosystems).

Genetic Risk Score Predicts Prostate Cancer Drug Response

Metastatic castration-resistant prostate cancer is when the cancer has spread to parts of the body other than the prostate, and it is able to grow and spread even though drugs or other treatments to lower the amount of male sex hormones are being used to manage the cancer. More...
20 Apr 2020
Image: Histopathology of classic medulloblastoma in the brain showing a diffuse pattern of tumor growth with poor cellular differentiation, nuclear molding, and minimal indistinct cytoplasm (Photo courtesy of Adekunle M. Adesina, MD, PhD)

Novel Inherited Mutation Predisposes Children to Medulloblastoma

Cancer genomics has revealed many genes and core molecular processes that contribute to human malignancies, but the genetic and molecular bases of many rare cancers remains unclear. Genetic predisposition accounts for 5% to 10% of cancer diagnoses in children. More...
16 Apr 2020
Image: Touch preparation smears from cases of various forms of lung injury with reactive pneumocytes, illustrating markedly enlarged and highly atypical epithelial cells retaining distinctive Napoleon hat–like shapes (Photo courtesy of Natasha Rekhtman, MD, PhD).

Reactive Pneumocytes Identified by Distinctive Cytology

One of the most challenging and exceedingly common diagnostic dilemmas in pulmonary pathology is the distinction between reactive and neoplastic epithelial atypia. In particular, reactive pneumocytes in various infectious or inflammatory lung diseases can exhibit marked cytological atypia, which can closely resemble malignancy. More...
15 Apr 2020
Image: The 96-capillary 3730xl DNA Analyzer is the Gold Standard for high throughput genetic analysis and used for Sanger sequencing (Photo courtesy of Thermo Fisher Scientific)

Susceptibility Gene Identified for Idiopathic Pulmonary Arterial Hypertension

Idiopathic pulmonary arterial hypertension (IPAH) is a lung disorder characterized by high blood pressure in the pulmonary arteries. In this instance, “idiopathic” means that the cause of the pulmonary artery hypertension is unknown. More...
14 Apr 2020
Image: Histological sections of a moderately well differentiated squamous cell carcinoma of the lung showing infiltrating sheets and tongues of malignant squamous cells with whorls of keratin (Photo courtesy of Department of Health Western Australia).

Liquid Biopsy Lung Cancer Screening Method Developed

Genomic blood tests for cancer screening and early detection have become the focus of attention in the molecular diagnostic space, though most activity so far has been either toward pan-cancer screening tools, or in a few other specific tumor types like colorectal cancer, where tests hope to vie against colonoscopy and existing stool-based methods. More...
09 Apr 2020
Image: Photomicrograph of a vaginal epithelial clue cell coated with Gardnerella vaginalis (Photo courtesy of Universidad Autónoma de Zacatecas).

Potential Microbial Markers Identified for Cervical Pre-Cancer Progression

Human papillomavirus (HPV) infection is one of the most common sexually transmitted infections. However, only a small percentage of high-risk (HR) HPV infections progress to cervical pre-cancer and cancer. The role of the cervicovaginal microbiome (CVM) in the natural history of HR-HPV has been investigated. More...
08 Apr 2020
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The Pathology channel details advances in the field of Surgical Pathology and all its subspecialties, including Cytopathology and its subspecialties.

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