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Pathology

Image: The MSI Analysis System, Version 1.2, is a fluorescent multiplex PCR-based method to detect microsatellite instability (MSI), a form of genomic instability (Photo courtesy of Promega).

Molecular Subtype Identified for CRCs Metastasized to Liver

Metastases are the leading cause of cancer-related deaths and frequently are widely disseminated, which has led to the prevailing view that metastases are always widespread. More...
17 May 2018
Image: A microscopic appearance of cell blocks prepared by the HistoGel + ethanol (EtOH) method versus HistoGel-only and the EtOH-only methods. The insets in C and F illustrate excellent cytomorphologic preservation with this method (Photo courtesy of Memorial Sloan Kettering Cancer Center).

Cell Block Prep Method Modified for Molecular Studies

Biomarker testing is currently required to guide the selection of a growing number of targeted therapies in patients with a wide range of malignancies. Combined with increasing use of immunostaining for tumor diagnosis, this has substantially increased the demand for the amount of tissue in small specimens. More...
14 May 2018
Image: A histopathology micrograph of anaplastic thyroid carcinoma (Photo courtesy of The Clayman Thyroid Cancer Center).

Thyroid Cancer Genetics Study Finds New Mutations

Anaplastic thyroid cancer (ATC) is a form of thyroid cancer, which has a very poor prognosis due to its aggressive behavior and resistance to cancer treatments. Its anaplastic cells have poor differentiation, including dedifferentiation. More...
08 May 2018
Image: A diagram of breast cancer detection using artificial neural network (Photo courtesy of Ben-Gurion University).

Breath and Urine Tests Detect Early Breast Cancer

Breast cancer is the most commonly diagnosed malignancy among females and the leading cause of death around the world. In 2016, breast cancer accounted for 29% of all new cancers identified in the USA and was responsible for 14% all cancer-related deaths. More...
08 May 2018
Image: The nanoLC-Ultra 1D+ for nanoflow liquid chromatography (Photo courtesy of Eksigent).

Biomarkers Identified for Irritable Bowel Syndrome

The causes of gastrointestinal complaints in irritable bowel syndrome (IBS) remain poorly understood. Altered nerve function has emerged as an important pathogenic factor as IBS mucosal biopsy supernatants consistently activate enteric and sensory neurons. More...
02 May 2018
Image: A diagram of the microfluidic device that uses magnetic particles and wavy-herringbone design to capture and release circulating tumor cells (Photo courtesy of Lehigh University).

Cancer Blood Test Engineered to Detect Tumors Early

A new innovative microfluidic device has been developed that uses magnetic particles and wavy-herringbone design to capture and release circulating tumor cells (CTC) with a high capture efficiency rate at different tumor cell concentrations. More...
02 May 2018
Image: The new streamlined approach discovered for diagnosing and treating bowel cancer (Photo courtesy of University of Adelaide).

Streamlined Approach Discovered for Treating Bowel Cancer

More than 4,000 Australians die from bowel cancer each year, and more than 17,000 new cases of this cancer will be diagnosed in 2018. Scientists are working to understand the genetic drivers of bowel cancer, with a special interest in those cancers which are the hardest to treat, and which have the poorest prognosis. More...
02 May 2018
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The Pathology channel details advances in the field of Surgical Pathology and all its subspecialties, including Cytopathology and its subspecialties.
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