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Pathology

Image: A histopathology image of hepatocellular carcinoma: the malignant cells seen mostly on the right are well differentiated and interdigitate with normal, larger hepatocytes seen mostly at the left (Photo courtesy of SPL).

Ascitic Fluid Lactoferrin Investigated in Liver Cirrhosis Patients

Although elevated levels of lactoferrin provide a biomarker for inflammatory bowel diseases and colorectal cancer, the clinical significance of these elevated levels in ascitic fluid of patients with ascites caused by liver cirrhosis is limited. More...
03 Nov 2016
Image: The Access Array microfluidic system generates next-generation sequencing (NGS) (Photo courtesy of Fluidigm).

Non-Invasive Assay Improves Surveillance of Solid-Organ Transplants

Patients who have received a solid organ transplant require lifelong immunosuppressive therapy. The threat of transplant rejection due to insufficient drug therapy must be balanced against increased risks of infections and cancer from excessive immunosuppression. More...
28 Oct 2016
Image: A histopathology of a moderately differentiated adenocarcinoma of colon showing a glandular configuration, but the glands are irregular and very crowded. Many of them have lumens containing bluish mucin (Photo courtesy of Raul Gonzalez MD).

Blood Test for Colorectal Cancer Recurrence Proves Highly Sensitive

When diagnosed early, before cancer has spread, the relative five-year survival rate for colorectal cancer (CRC) is 90%, but only approximately four out of 10 CRC cases are detected early. More...
27 Oct 2016
Image: The discovery of two classes of Crohn\'s has implications for scientists to deliver more targeted treatments (Photo courtesy of MNT).

Gene Activity Mapping Points to Two Subtypes of Crohn's Disease

Gene activity studies have found that there are two clinically relevant forms of Crohn's disease that are defined by molecular signatures that are not linked to tissue sampling location, patient age, or treatment status. More...
26 Oct 2016

Respiratory Tract Bacterium Triggers Serious Nervous System Disease

Guillain-Barré syndrome (GBS) is an acute post infectious immune-mediated polyneuropathy and an acute life-threatening disease of the nervous system that leads to sensory disturbances and acute flaccid paralysis. More...
20 Oct 2016
Image: A photomicrograph of Prion Protein immunostaining from a biopsy in a patient with variant Creutzfeldt-Jakob Disease (Photo courtesy of SPL).

Urine Test Could Diagnose Sporadic Creutzfeldt-Jakob Disease

Prions are infectious agents that cause invariably fatal brain diseases such as Creutzfeldt-Jakob Disease (CJD) in humans, scrapie in sheep and bovine spongiform encephalopathy (BSE or 'mad cow disease') in cattle. More...
20 Oct 2016
Image: Immuno-wall chips with the photo reactive polymer in the center of the 40 microchannels are made with a biotinylated anti-R132H-IDH1 antibody (HMab-2), an anti-wild-type IDH1 antibody (RcMab-1), and fluorescent antibodies. It shows sensitive and specific fluorescence from mutant IDH1 (Photo courtesy of Nagoya University).

Novel Device Enables Rapid Identification of Brain Cancer Type

A device has been developed for quick, accurate identification of a mutation strongly associated with a cancer that affects the central nervous system, potentially enabling accurate removal of the entire tumor during an operation. More...
20 Oct 2016
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The Pathology channel details advances in the field of Surgical Pathology and all its subspecialties, including Cytopathology and its subspecialties.

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