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Pathology

Image: Schematic diagram of the Liquid Biopsy platform LiqBiopSens concept (Photo courtesy of AWSensors).

High-Sensitivity Molecular Detection System Used in Cancer Screening

The current go-to method for reliable cancer diagnosis is tumor tissue biopsy, but this method is invasive, painful and expensive and it also only provides information of a single point in the evolution of the disease.  More...
04 Jan 2016
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Immunomarker Expression Clarified for Thoracic Tumors

Comprehensive morphological and immunohistochemical subtyping of tumors is of growing importance for therapy selection and propelled the concept of a tumor-specific, individualized treatment.   More...
03 Jan 2016
Image: Immunohistochemistry of an estrogen receptor-positive breast cancer surgical pathology specimen; most of the cancer cell nuclei stain strongly positive (dark brown) for estrogen receptor (ER) (Photo courtesy of Dr. Ronald S. Weinstein, MD).

Commercial Assay Aids Physicians in Tamoxifen Drug Monitoring

A laboratory developed test could help assess levels of several tamoxifen drug metabolites in a blood specimen which is important as five years of therapy with tamoxifen has been the standard of care for women with early stage, estrogen-receptor-positive breast cancer following "curative" surgery.   More...
30 Dec 2015
Image: Immunohistochemistry of PIK3CA mutations in a breast cancer specimen (Photo courtesy of Prof. Sibylle Loibl, MD, PhD).

Blood Test Helps Tailor Treatments for Advanced Breast Cancer

Information gleaned from a liquid biopsy may help predict how individual women with advanced breast cancer will respond to certain therapies as well as reveal genetic mutations that can impact prognosis.   More...
29 Dec 2015
Image: Micrograph from a prostate biopsy showing a prostatic adenocarcinoma, conventional (acinar) type, the most common form of prostate cancer (Photo courtesy of Nephron).

Prostate Cancer Screening Improved by Repeating Abnormal Tests

For more than 20 years, the prostate-specific antigen test has been used to help screen for prostate cancer, but in recent years, some task forces have called for this blood test to be abandoned because it leads to many unnecessary biopsies.  More...
29 Dec 2015
Image: Micrograph of a seminoma, a common germ cell tumor (Photo courtesy of Wikimedia Commons).

PCR-Based Blood Test Diagnoses Rare Childhood Germ Cell Cancer

A team of British researchers has developed a noninvasive, low cost blood test for the diagnosis of rare childhood germ cell cancer.  More...
28 Dec 2015
Image: The minichromosome maintenance complex component 5 (Mcm5)-enzyme-linked immunosorbent assay (ELISA) kit (Photo courtesy of Arquer Diagnostics Ltd.).

Urine Test Helps Diagnose Bladder Cancer

Bladder cancer is the seventh most common type in the UK, with around 10,000 people diagnosed every year and around two-thirds of cases recur within five years, so patients are monitored routinely after treatment.    More...
22 Dec 2015
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The Pathology channel details advances in the field of Surgical Pathology and all its subspecialties, including Cytopathology and its subspecialties.

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