Meeting Seeks to Boost Interest in the Human Proteome Project

To accomplish this feat the research will proceed in two main directions: chromosome-based HPP (cHPP), focusing on annotating subsets of proteins for each chromosome, and biology disease-driven HPP (bdHPP), aiming to answer biological and disease-related questions.

The practical work of identifying, quantifying, and annotating all human protein-coding genes, the will be accomplished with three primary tools: mass spectrometry, antibody affinity, and bioinformatics. For each of these methods the HPP will be publishing guidelines with recommendations for experimental procedures, sample handling, and data analysis.

The major challenges for the HPP at this time are the need to convince enough large research laboratories to join the consortium, and to ensure sufficient quantitation in order to develop large-scale databases. The ultimate goal is to produce high-quality results that will be universally available to researchers all over the world. In the long term, the HPP aims to take proteomics beyond research and into clinical applications.

Related Links:
AB SCIEX
Human Proteome Organization