Novel Mass Spectroscopy-Based Analysis System May Revolutionize Proteomics Research

An American-Swiss collaborative effort has resulted in a new mass spectrometry-based proteomics research method that can quantify nearly all peptides and proteins in a sample from a single analysis.

A team comprised of investigators from the Swiss Federal Institute of Technology (ETH Zurich; Switzerland) and their colleagues from the American company AB SCIEX (Framingham, MA, USA) have completed development of the groundbreaking mass spectrometry system, MS/MSALL with SWATH Acquisition.

This system, which is fully described in the January 18, 2012, online edition of the journal Molecular and Cellular Proteomics, uses a data-independent MS/MS acquisition method to systematically generate complete, high-specificity fragment ion maps that can be queried for the presence and quantity of any protein of interest using a targeted data analysis strategy. More...