We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress hp
Sign In
Advertise with Us
LGC Clinical Diagnostics

Download Mobile App




New Assay Detects Rapidly Emerging Strains of Antibiotic-Resistant Enterobacteriaceae

By LabMedica International staff writers
Posted on 02 Oct 2012
Print article
A molecular assay for detecting the three major antibiotic resistance genes acquired by strains of the pathogenic carbapenem-resistant Enterobacteriaceae (CRE) is now being made available as a research tool and as part of an effort to gather feedback on its potential clinical diagnostic performance.

Becton, Dickinson and Company (BD; Franklin Lakes, NJ, USA) has now released a research use only (RUO) molecular test designed to rapidly detect antibiotic resistance genes in highly pathogenic CRE resistant to nearly all available antibiotics; in some cases there are no treatments effective against CRE infections. The assay is performed on the automated BD MAX System and produces results in just two hours, compared to several days for conventional culture methods.

BD is making the assay available for RUO to a limited number of infectious disease experts and researchers. “We are offering this assay initially as a research tool to help BD and infectious disease researchers explore its clinical utility while we pursue development of an in vitro diagnostic solution,” said Patrick Murray, PhD, Worldwide Director of Scientific Affairs, BD Diagnostics - Diagnostic Systems.

Global incidence of CRE infections has increased dramatically over the past decade. CRE, “now routinely cause both community- and hospital-acquired infections. The medical community urgently needs more rapid and accurate [CRE detection] methods,” said Dr. Brian Currie, vice president and Medical Director for Research at Montefiore Medical Center and Assistant Dean for Clinical Research at the Albert Einstein College of Medicine. The most concerning are CRE that have acquired carbapenemase genes including KPC, NDM, and OXA-48. The BD MAX assay is the first automated assay to detect all three of these genes directly from specimens.

The BD MAX System is the first and only automated, bench-top system designed to perform a broad range of molecular tests. This includes in vitro diagnostic (IVD) assays, as well as user-defined protocols and life science research applications. More than 15 state-of-the-art assays are currently under development. Assays already available for clinical IVD use on the BD MAX System include methicillin-resistant Staphylococcus aureus (MRSA) and toxigenic Clostridium difficile, both CE-marked for IVD use in Europe. The MRSA assay was FDA-cleared with CLIA Moderate Complexity categorization earlier this year. The toxigenic C. difficile assay has been submitted to the FDA for 510(k) review and clearance.

Related Links:
Becton, Dickinson and Company

Gold Member
TORCH Panel Rapid Test
Rapid TORCH Panel Test
Antipsychotic TDM AssaysSaladax Antipsychotic Assays
New
Hepato Fibrosis Assays
Hepato Fibrosis Assays
New
Chlamydia Test Kit
CHLAMYTOP

Print article

Channels

Clinical Chemistry

view channel
Image: The new saliva-based test for heart failure measures two biomarkers in about 15 minutes (Photo courtesy of Trey Pittman)

POC Saliva Testing Device Predicts Heart Failure in 15 Minutes

Heart failure is a serious condition where the heart muscle is unable to pump sufficient oxygen-rich blood throughout the body. It ranks as a major cause of death globally and is particularly fatal for... Read more

Hematology

view channel
Image: QScout CBC will give a complete blood count in 2 minutes from fingerstick or venous blood (Photo courtesy of Ad Astra Diagnostics)

Next Gen CBC and Sepsis Diagnostic System Targets Faster, Earlier, Easier Results

Every hour is critical in protecting patients from infections, yet there are currently limited tools to assist in early diagnosis before patients reach a hospital. The complete blood count (CBC) is a common... Read more

Immunology

view channel
Image: An immune response is initiated when an antigen-presenting cell (pink) presents foreign material to a T-cell (blue) (Photo courtesy of JAX)

Advanced Imaging Method Maps Immune Cell Connections to Predict Cancer Patients Survival

A growing tumor is influenced not only by the tumor cells themselves but also by the surrounding tissue, which alters its biology. Immune cells communicate by transferring vital signaling proteins to their... Read more

Microbiology

view channel
Image: The InfectoSynovia test has the potential to revolutionize the diagnosis of periprosthetic joint infection (Photo courtesy of 123RF)

High-Accuracy Bedside Test to Diagnose Periprosthetic Joint Infection in Five Minutes

Periprosthetic joint infection (PJI) represents a significant global issue that is worsening as the number of joint replacements increases due to aging populations. In the United States alone, the anticipated... Read more

Pathology

view channel
Image: LMU’s Professor Frederick Klauschen developed the novel approach that can improve diagnostic accuracy (Photo courtesy of LMU Munich)

AI Tool Uses Imaging Data to Detect Less Frequent GI Diseases

Artificial intelligence (AI) is already being utilized in various medical fields, demonstrating significant potential in aiding doctors in diagnosing diseases through imaging data. However, training AI... Read more
Copyright © 2000-2024 Globetech Media. All rights reserved.