Imaging Platform Characterizes Particles Using Raman Spectroscopy

New imaging technology combines automated particle imaging with chemical identification of individual particles using Raman spectroscopy. This automated system measures particle size, shape, and chemical identity in a single platform.

Following the completion of an effective early access program, the Morphologi G3-ID particle characterization system has been launched to the global market. The Morphologi G3-ID, developed by Malvern Instruments (Malvern, UK; www.malvern.com), is designed to unravel complicated particle characterization problems where particle size and shape do not provide adequate data. The early access program was designed to enable users to explore specific applications and to allow full optimization of the product features. Major applications for which it is establishing itself to be particularly valuable are in determining component-specific particle properties of mixtures and blends, such as the particle size of drug materials in asthma inhalers and nasal sprays, and, for instance, in the identification of unknown or suspicious particles in injectable or parenteral products.

The Morphologi G3-ID is designed to meet a wide variety of requirements and to enable all users, from particle characterization scientists with some degree of spectroscopy expertise through to experienced spectroscopists, to gain an in-depth understanding of particulate samples. Simple standard operating procedure (SOP) takes the user from integrated sample dispersion for dry powders through to shape, size, and chemical analysis, with automatic selection, targeting and chemical classification of thousands of individual particles. Measurements can be generated on dry powders, membrane filters, and suspensions.

Malvern Instruments is a developer of measuring performance-controlling material characteristics. These include particle shape and size, zeta potential, molecular weight, size, and conformation, rheologic characteristics and chemical identification. Malvern’s measurement systems for scientists, technologists, and engineers are engineered through customer collaboration. Complementary materials characterization systems provide interrelated measurements that reflect the complexities of particulates and disperse systems, macromolecules, and nanomaterials.

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