We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress hp
Sign In
Advertise with Us
INTEGRA BIOSCIENCES AG

Download Mobile App




Molecule in Green Tea Used as Carrier for Anticancer Proteins

By LabMedica International staff writers
Posted on 16 Oct 2014
Print article
A molecule that is a key ingredient in green tea can be employed as a carrier for anticancer proteins, forming a stable and effective therapeutic nanocomplex. This new discovery could help to construct better drug-delivery systems.

Some cancer treatments depend on medication comprising the therapeutic drug and a carrier that transports the drug to the tumor site. When designing drug carriers, several factors must be considered, for instance, it must be specific so that it only fights the tumor. Moreover, the drug-to-carrier ratio is important because using high quantities of the carrier could result in toxicity if the body cannot metabolize it. Furthermore, the complex will be ineffective if the body attacks and eliminates it too rapidly.

Joo Eun Chung and colleagues, from the Institute of Bioengineering and Nanotechnology (Singapore), used the molecule epigallocatechin-3-O-gallate (EGCG), which is found in high quantities in green tea, to create a carrier for the anticancer protein Herceptin. The advantage of EGCG over other carriers is that it also has anticancer effects.

The scientists injected the EGCG-Herceptin nanocomplex into mice and discovered that it showed better tumor selectivity and growth reduction, as well as lasting longer in the blood, which could increase its effectiveness than if Herceptin was injected alone.

The investigators published their findings published online October 5, 2014, in the journal Nature Nanotechnology.

Related Links:

Institute of Bioengineering and Nanotechnology


New
Gold Member
ANA & ENA Screening Assays
ANA and ENA Assays
Unit-Dose Packaging solution
HLX
New
Human Immunodeficiency Virus Assay
RealLine HIV Quantitative Kit
New
Gold Member
Anti-CCP Kit
BioPlex 2200 Anti-CCP

Print article

Channels

Clinical Chemistry

view channel
Image: The new saliva-based test for heart failure measures two biomarkers in about 15 minutes (Photo courtesy of Trey Pittman)

POC Saliva Testing Device Predicts Heart Failure in 15 Minutes

Heart failure is a serious condition where the heart muscle is unable to pump sufficient oxygen-rich blood throughout the body. It ranks as a major cause of death globally and is particularly fatal for... Read more

Molecular Diagnostics

view channel
Image: Schematic overview of maternal biomarker discovery using cell-free RNA during pregnancy (Photo courtesy of Circulation Research (2024). DOI: 10.1161/CIRCRESAHA.124.325024)

Maternal Blood Test Identifies Congenital Heart Diseases in Fetus

Each year, around 1,000 children are born with a single ventricle heart defect (SVHD), a condition where one of the heart's lower chambers is underdeveloped, too small, or missing a valve.... Read more

Hematology

view channel
Image: QScout CBC will give a complete blood count in 2 minutes from fingerstick or venous blood (Photo courtesy of Ad Astra Diagnostics)

Next Gen CBC and Sepsis Diagnostic System Targets Faster, Earlier, Easier Results

Every hour is critical in protecting patients from infections, yet there are currently limited tools to assist in early diagnosis before patients reach a hospital. The complete blood count (CBC) is a common... Read more

Microbiology

view channel
Image: The InfectoSynovia test has the potential to revolutionize the diagnosis of periprosthetic joint infection (Photo courtesy of 123RF)

High-Accuracy Bedside Test to Diagnose Periprosthetic Joint Infection in Five Minutes

Periprosthetic joint infection (PJI) represents a significant global issue that is worsening as the number of joint replacements increases due to aging populations. In the United States alone, the anticipated... Read more

Pathology

view channel
Image

AI-Based Method Shows Promise for Pathological Diagnosis of Hereditary Kidney Diseases

Alport syndrome is a hereditary kidney disorder characterized by kidney dysfunction, sensorineural hearing loss, and ocular abnormalities. Early in the disease, patients experience hematuria, which is... Read more
Copyright © 2000-2024 Globetech Media. All rights reserved.