We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress hp
Sign In
Advertise with Us
LGC Clinical Diagnostics

Download Mobile App




Lipidomics Study Highlights Interaction of Aspirin with Omega-6 Fatty Acids to Lower Cholesterol Levels

By LabMedica International staff writers
Posted on 27 Oct 2014
Print article
Image: A space filling diagram of arachidonic acid, which has been linked to the way the body deals with cholesterol and is intimately related to the risk of developing cardiovascular disease (Photo courtesy of Wikimedia Commons).
Image: A space filling diagram of arachidonic acid, which has been linked to the way the body deals with cholesterol and is intimately related to the risk of developing cardiovascular disease (Photo courtesy of Wikimedia Commons).
A recent paper described how metabolism centered on the omega-6 polyunsaturated fatty acid arachidonic acid (AA) is linked to the way the body deals with cholesterol, which is intimately related to the risk of developing cardiovascular disease.

Investigators at Innsbruck Medical University (Austria) combined data from a genome-wide association study (GWAS) that screened more than 100,000 individuals of European ancestry with results from studies of mediator lipidomics and from functional validation studies carried out in mice.

Lipidomics, the systematic decoding of lipid-based information in biosystems, is comprised of identification and profiling of lipids and lipid-derived mediators. It is an emerging field of biomedical research that includes complex lipidome analysis. A lipidome is the comprehensive and quantitative description of a set of lipid species present in an organism. Lipidomics involves systems-level identification and quantization of thousands of pathways and networks of cellular lipids molecular species and their interactions with other lipids, proteins, and other moieties in vivo.

Results presented in a paper published in the October 16, 2014, online edition of the journal Cell Metabolism showed that the Alox5 (arachidonate 5-lipoxygenase) gene, which encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid was closely associated with plasma cholesterol and HDL (high density lipoprotein)-cholesterol. Another group of Alox5 products, the lipoxins, was found to interact with aspirin to reduce levels of circulating cholesterol by increasing expression by liver cells of the gene for the bile salt export pump Abcb11 (ATP-binding cassette, sub-family B member 11).

Abcb11 is a membrane-associated protein and is a member of the superfamily of ATP-binding cassette (ABC) transporters and a member of the MDR/TAP subfamily. This particular protein is responsible for the transport of taurocholate and other cholate conjugates from liver cells to the bile. In humans, the activity of this transporter is the major determinant of bile formation and bile flow. Induction of Abcb11 enhanced reverse cholesterol transport, one key function of HDL.

"Aspirin is known to prevent cardiovascular disease due to its anti-thrombotic and anti-inflammatory effects. We now identified a third mechanism by which aspirin may confer protection," said senior author Dr. Ivan Tancevski, an internist at Innsbruck Medical University. "Our findings could help pave the way for novel therapeutic approaches to prevent cardiovascular disease and its associated clinical sequelae, including heart attacks and stroke."

Related Links:
Innsbruck Medical University


Gold Member
Turnkey Packaging Solution
HLX
Antipsychotic TDM AssaysSaladax Antipsychotic Assays
New
Vibrio Cholerae O1/O139 Rapid Test
StrongStep Vibrio Cholerae O1/O139 Antigen Combo Rapid Test
New
Histamine ELISA
Histamine ELISA

Print article

Channels

Clinical Chemistry

view channel
Image: The new saliva-based test for heart failure measures two biomarkers in about 15 minutes (Photo courtesy of Trey Pittman)

POC Saliva Testing Device Predicts Heart Failure in 15 Minutes

Heart failure is a serious condition where the heart muscle is unable to pump sufficient oxygen-rich blood throughout the body. It ranks as a major cause of death globally and is particularly fatal for... Read more

Hematology

view channel
Image: The smartphone technology measures blood hemoglobin levels from a digital photo of the inner eyelid (Photo courtesy of Purdue University)

First-Of-Its-Kind Smartphone Technology Noninvasively Measures Blood Hemoglobin Levels at POC

Blood hemoglobin tests are among the most frequently conducted blood tests, as hemoglobin levels can provide vital insights into various health conditions. However, traditional tests are often underutilized... Read more

Immunology

view channel
Image: Under a microscope, DNA repair is visible as bright green spots (“foci”) in the blue-stained cell DNA. Orange highlights actively growing cancer cells (Photo courtesy of WEHI)

Simple Blood Test Could Detect Drug Resistance in Ovarian Cancer Patients

Every year, hundreds of thousands of women across the world are diagnosed with ovarian and breast cancer. PARP inhibitors (PARPi) therapy has been a major advancement in treating these cancers, particularly... Read more

Microbiology

view channel
Image: HNL Dimer can be a novel and potentially useful clinical tool in antibiotic stewardship in sepsis (Photo courtesy of Shutterstock)

Unique Blood Biomarker Shown to Effectively Monitor Sepsis Treatment

Sepsis remains a growing problem across the world, linked to high rates of mortality and morbidity. Timely and accurate diagnosis, along with effective supportive therapy, is essential in reducing sepsis-related... Read more
Copyright © 2000-2024 Globetech Media. All rights reserved.