We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress hp
Sign In
Advertise with Us
LGC Clinical Diagnostics

Download Mobile App




New ELISA Kit Measures Histamine in Diverse Biological Specimens

By LabMedica International staff writers
Posted on 05 Feb 2015
Print article
Image: The Histamine ELISA kit (Photo courtesy of Enzo Life Science).
Image: The Histamine ELISA kit (Photo courtesy of Enzo Life Science).
A newly released ELISA kit measures histamine or N-methyl histamine in a wide variety of biological specimens.

Histamine is an organic nitrogen compound involved in local immune responses as well as regulating physiological function in the gut and acting as a neurotransmitter. Histamine triggers the inflammatory response. As part of an immune response to foreign pathogens, histamine is produced by basophils and by mast cells found in nearby connective tissues. Histamine increases the permeability of the capillaries to white blood cells and some proteins, to allow them to engage pathogens in the infected tissues. Increased vascular permeability in the nasal passages causes fluid to escape from capillaries into the tissues, which leads to the classic symptoms of an allergic reaction: a runny nose and watery eyes. Allergens can bind to IgE-loaded mast cells in the nasal cavity's mucous membranes. This can lead to three clinical responses: sneezing due to histamine-associated sensory neural stimulation, hyper-secretion from glandular tissue nasal congestion due to vascular engorgement associated with vasodilation, and increased capillary permeability. The half-life of histamine in a biological system is about four minutes before its conversion to the longer lived N-methyl histamine, which is present in the urine.

A new kit—for research use only—for the determination of histamine and N-methyl histamine has been released by Enzo Life Sciences (Farmingdale, NY, USA). The Histamine ELISA kit, which can analyze up to 40 samples in duplicate in less than two hours, measures as little as 0.03 nanograms per milliliter of histamine in serum, plasma, urine, or tissue culture medium. The Histamine ELISA kit contains all materials required to perform the assay. It is supplied with an easy-to-follow protocol, pre-coated break-a-part microtiter plate, and liquid color-coded reagents that save time and reduce errors.

Related Links:

Enzo Life Sciences



New
Gold Member
Pneumocystis Jirovecii Detection Kit
Pneumocystis Jirovecii Real Time RT-PCR Kit
Automated Blood Typing System
IH-500 NEXT
New
Newborn Screening Test
NeoMass AAAC 3.0
New
Alpha-1-Antitrypsin ELISA
IDK alpha-1-Antitrypsin ELISA

Print article

Channels

Clinical Chemistry

view channel
Image: The new saliva-based test for heart failure measures two biomarkers in about 15 minutes (Photo courtesy of Trey Pittman)

POC Saliva Testing Device Predicts Heart Failure in 15 Minutes

Heart failure is a serious condition where the heart muscle is unable to pump sufficient oxygen-rich blood throughout the body. It ranks as a major cause of death globally and is particularly fatal for... Read more

Hematology

view channel
Image: The smartphone technology measures blood hemoglobin levels from a digital photo of the inner eyelid (Photo courtesy of Purdue University)

First-Of-Its-Kind Smartphone Technology Noninvasively Measures Blood Hemoglobin Levels at POC

Blood hemoglobin tests are among the most frequently conducted blood tests, as hemoglobin levels can provide vital insights into various health conditions. However, traditional tests are often underutilized... Read more

Immunology

view channel
Image: Under a microscope, DNA repair is visible as bright green spots (“foci”) in the blue-stained cell DNA. Orange highlights actively growing cancer cells (Photo courtesy of WEHI)

Simple Blood Test Could Detect Drug Resistance in Ovarian Cancer Patients

Every year, hundreds of thousands of women across the world are diagnosed with ovarian and breast cancer. PARP inhibitors (PARPi) therapy has been a major advancement in treating these cancers, particularly... Read more

Microbiology

view channel
Image: HNL Dimer can be a novel and potentially useful clinical tool in antibiotic stewardship in sepsis (Photo courtesy of Shutterstock)

Unique Blood Biomarker Shown to Effectively Monitor Sepsis Treatment

Sepsis remains a growing problem across the world, linked to high rates of mortality and morbidity. Timely and accurate diagnosis, along with effective supportive therapy, is essential in reducing sepsis-related... Read more
Copyright © 2000-2024 Globetech Media. All rights reserved.