We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress hp
Sign In
Advertise with Us
LGC Clinical Diagnostics

Download Mobile App




New Approach to Diabetes Based on Microneedle Smart Patch Insulin Delivery

By LabMedica International staff writers
Posted on 02 Feb 2017
Print article
Image: Tiny, painless microneedles on a patch can deliver insulin in response to rising glucose levels (Photo courtesy of the ACS).
Image: Tiny, painless microneedles on a patch can deliver insulin in response to rising glucose levels (Photo courtesy of the ACS).
A novel "microneedle smart patch" has been developed that was designed to automatically correct glucose imbalance in patients with type I or advanced type II diabetes.

An interdisciplinary team of investigators at North Carolina State University and the University of North Carolina designed a smart patch comprising microneedles made from block copolymer incorporated with polyethylene glycol (PEG) and phenylboronic ester (PBE)-conjugated polyserine.

The device, which integrated H2O2-responsive polymeric vesicles (PVs) with a transcutaneous microneedle-array patch, were loaded with the enzyme glucose oxidase (GOx) and insulin. The microneedles functioned as both moieties of the glucose sensing element (GOx) and the insulin release actuator to provide basal insulin release as well as promote insulin release in response to hyperglycemic states.

Results reported in the current study, which was published in the January 4, 2017, online edition of the journal ACS Nano, revealed that insulin release responded quickly to elevated glucose and that its kinetics could be modulated by adjusting the concentration of GOx loaded into the microneedles. Using a mouse diabetes model, the investigators showed that a single patch could regulate glucose levels effectively with reduced risk of hypoglycemia.

Gold Member
Flocked Fiber Swabs
Puritan® Patented HydraFlock®
Antipsychotic TDM AssaysSaladax Antipsychotic Assays
New
Tabletop Centrifuge
Mikro 185
New
Vitamin B12 Test
CHORUS CLIA VIT B12

Print article

Channels

Clinical Chemistry

view channel
Image: The new saliva-based test for heart failure measures two biomarkers in about 15 minutes (Photo courtesy of Trey Pittman)

POC Saliva Testing Device Predicts Heart Failure in 15 Minutes

Heart failure is a serious condition where the heart muscle is unable to pump sufficient oxygen-rich blood throughout the body. It ranks as a major cause of death globally and is particularly fatal for... Read more

Hematology

view channel
Image: The smartphone technology measures blood hemoglobin levels from a digital photo of the inner eyelid (Photo courtesy of Purdue University)

First-Of-Its-Kind Smartphone Technology Noninvasively Measures Blood Hemoglobin Levels at POC

Blood hemoglobin tests are among the most frequently conducted blood tests, as hemoglobin levels can provide vital insights into various health conditions. However, traditional tests are often underutilized... Read more

Immunology

view channel
Image: Under a microscope, DNA repair is visible as bright green spots (“foci”) in the blue-stained cell DNA. Orange highlights actively growing cancer cells (Photo courtesy of WEHI)

Simple Blood Test Could Detect Drug Resistance in Ovarian Cancer Patients

Every year, hundreds of thousands of women across the world are diagnosed with ovarian and breast cancer. PARP inhibitors (PARPi) therapy has been a major advancement in treating these cancers, particularly... Read more

Microbiology

view channel
Image: HNL Dimer can be a novel and potentially useful clinical tool in antibiotic stewardship in sepsis (Photo courtesy of Shutterstock)

Unique Blood Biomarker Shown to Effectively Monitor Sepsis Treatment

Sepsis remains a growing problem across the world, linked to high rates of mortality and morbidity. Timely and accurate diagnosis, along with effective supportive therapy, is essential in reducing sepsis-related... Read more
Copyright © 2000-2024 Globetech Media. All rights reserved.