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BioResearch

Image: Mammary tumors caused by deleting CCN6 in a mouse model look like human metaplastic carcinoma (Photo courtesy of the University of Michigan).

New Model to Aid Research on Rare Type of Aggressive Breast Cancer

Cancer researchers have created a new mouse model that will allow them to study in vivo the molecular factors linked to the development of metaplastic breast cancer, a rare form of triple-negative breast cancer. More...
17 Jan 2017
Image: A photomicrograph showing numerous immune suppressive cells in green and yellow, infiltrating the tumor mass (tumor cells in white). By depleting these immune suppressive cells, immunotherapy becomes much more effective (Photo courtesy of the University of Michigan).

Combined Gene and Immunotherapy Shows Potential for Aggressive Brain Tumors

A novel approach that combined gene and immunotherapy demonstrated considerable potential in a mouse model as a method for treating the aggressive brain tumor glioblastoma multiforme (GBM). More...
17 Jan 2017
Image: An artist’s conception of nanoparticle-carrying immune cells that target tumors and release drug-loaded nanoparticles for cancer treatment (Photo courtesy of Jian Yang and Yixue Su, Pennsylvania State University).

Researchers Demonstrate Potential of Drug Delivery System for Melanoma

A novel delivery system for anticancer drugs is based on biodegradable theranostic nanoparticles transported by immune cells that are naturally attracted to the site of the growing tumor. More...
12 Jan 2017
Image: A ball-and-stick model of the metformin molecule (Photo courtesy of Wikimedia Commons).

Drug Combination Selectively Prevents Cancer Cell Growth

The antihypertension drug syrosingopine has been found to drastically reduce the concentration of the diabetes medication metformin required to destroy cancer cells in culture and in a mouse liver cancer model. More...
12 Jan 2017
Image: The molecular model of the protein IkappaBalpha (NF-kappaB inhibitor, alpha) (Photo courtesy of Wikimedia Commons).

Interrupting a Molecular Signaling Pathway to Treat Prostate Cancer

Cancer researchers have traced a molecular pathway that is active in treatment resistant prostate cancer and have suggested therapeutic strategies to circumvent it. More...
11 Jan 2017
Image: Long noncoding RNAs (lncRNAs), which extend longer than 200 nucleotides, have emerged as additional important players in the control of gene expression. They fine-tune the expression of numerous genes and direct the activity of complex regulatory pathways, often in a cell- and developmental-stage-specific manner (Photo courtesy of Julia Yellow).

Polypeptide Encoded by Non-Coding RNA Regulates Muscle Regeneration

Their name notwithstanding, long non-coding RNAs (lncRNAs) have been found to actually encode synthesis of small polypeptides that can fine-tune the activity of critical cellular components. More...
11 Jan 2017
Image: A model of the L-selectin homing receptor protein (Photo courtesy of Wikimedia Commons).

Mechanism Found Blocks Activity of Anti-Cancer Lymphocytes

Cancer researchers have found that myeloid-derived suppressor cells, cells that help tumors avoid recognition by the body's immune system, work by stripping a molecule from the surface of lymphocytes, which they require for entry into the lymph nodes. More...
10 Jan 2017
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BioResearch brings the latest research news on the genome, proteome, metabolome, on drug discovery, and therapeutics. Biotech researchers, lab administrators, technologists, drug manufacturers, and suppliers can find the latest research news and information related to their fields of endeavor here.
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