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Molecular Diagnostics

Image: Morphologic variants of triple-negative breast cancer (TNBC) with different genetic alterations. A: TNBC with basal-like histologic features containing a prominent stromal lymphocytic infiltrate; this tumor had MYC amplification. B: TNBC with apocrine differentiation and a PI3KCA mutation. The tumor cells have abundant eosinophilic cytoplasm, round nuclei, and prominent nucleoli (Photo courtesy of Geisel School of Medicine).

Liquid Biopsy Detects Breast Cancer Residual Disease

 The concept of circulating DNA or tumor cells to identify patients with residual cancer present after early-stage, putatively curative treatment has made rapid strides across multiple tumor types since some of the first promising tests in colorectal cancer. More...
02 Jan 2020
Image: Electron micrograph of a bladder cancer cell: clinical pathology tests outperform molecular subtyping in bladder cancer (Photo courtesy of Jim Stallard).

Standard Pathology Tests Outperform Molecular Subtyping in Bladder Cancer

 Evolving diagnostic approaches include compiling databanks on gene expression and mutations present in a cancer type to find patterns of gene expression that are then used to subtype tumors that "pathologically look similar" but are molecularly different. More...
02 Jan 2020
Image: The NUCLISENS EASYMAG instrument is designed to meet the most critical needs when it comes to premium quality total nucleic acid extraction. The system automates an enhanced magnetic silica version of BOOM technology, a gold standard for efficient universal extraction of RNA and DNA (Photo courtesy of bioMérieux).

Asthma Severity Linked to Microbiome of Upper Airway

More than six million children under the age 18 have asthma in the USA. Asthma exacerbations have high impact on children, their families, the health care system, and may lead to subsequent decline in lung function. More...
01 Jan 2020
Image: Abnormal accumulation of tau protein in neuronal cell bodies (arrow) and neuronal extensions (arrowhead) in the neocortex of a patient who had died with Alzheimer\'s disease. Tau protein was stained brown using immunohistochemistry. The bar represents a distance of 25 microns (0.025 millimeters). (Photo courtesy of Wikimedia Commons)

Memory Loss in Alzheimer’s Disease Linked to Both Amyloid Plaques and Tau Tangles

 A team of neurodegenerative disease researchers has linked the APOE-epsilon-4 gene to increased formation of toxic tau protein aggregates (tangles) as well as amyloid-beta plaques in individuals with Alzheimer’s disease (AD). More...
31 Dec 2019
Image: Representation of the structure of apolipoprotein(a), a unique protein component of lipoprotein(a) (Photo courtesy of Wikimedia Commons)

Elevated Levels of Lipoprotein(a) Increase Cardiovascular Disease Risk in Patients with Type I Diabetes

 Results obtained by a team of Swedish researchers indicated that individuals with type I diabetes were at greater risk of developing cardiovascular disease (CVD) if they had elevated levels of lipoprotein(a) in their blood. More...
30 Dec 2019
Image: Each dot seen in this PRAM image represents one microRNA that has bound to the sensor (Photo courtesy of Nantao Li, University of Illinois)

Novel Liquid Biopsy Method for Detection of Cancer MicroRNA Biomarkers

 The potential usefulness of the “liquid biopsy” approach for detection of cancer biomarkers in the blood has been increased by the development of a method for capturing and counting cancer-associated microRNAs. More...
30 Dec 2019
Image: The cancer screening platform was a  multitarget stool DNA test (MT-sDNA), that uses multiple biomarkers to ensure the highest levels of sensitivity (Photo courtesy of Exact Sciences Laboratory)

Stool DNA Test Helps Detect Precancerous Lesions

 Colorectal cancer (CRC) is the third most common cancer and is one of the leading causes of cancer-related mortality. Although CRC incidence is increasing, a decrease in mortality has been observed due to the implementation of CRC screening and improved therapies. More...
27 Dec 2019
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Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.
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