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Pathology

Image: Schematic diagram of How Human Microbiota Flagellins Drive Adaptive Immune Responses in Crohn’s Disease (Photo courtesy of University of Alabama at Birmingham)

Human Microbiota Flagellins Drive Adaptive Immune Responses in Crohn’s Disease

Crohn's disease and ulcerative colitis, another type of inflammatory bowel disease (IBD), are characterized by dysregulated adaptive immune responses to the microbiota in genetically susceptible individuals, but the human specificity of these responses had so far been largely undefined. More...
20 May 2021
Image: Standard hematoxylin-eosin sections are unaffected by processing and imaging by clearing histology with multiphoton microscopy (CHiMP). Portions of the same core biopsy were submitted directly to standard processing (A) or processed by CHiMP and subsequently embedded in paraffin, sectioned, and stained (B), showing equivalent coloration and morphology (Photo courtesy of Yale School of Medicine)

Rapid, Direct-to-Digital Prostate Biopsy Pathology Evaluated

Increasing adoption of digital pathology promises marked improvements in reproducibility, efficiency, and accuracy of tissue-based diagnostics by facilitating routine remote expert consultation and enabling computerized image analysis for clinical use. More...
13 May 2021
Image: The HISCL-5000 is a fully automated immunoassay system designed for fast, highly sensitive and reliable immunoassay testing (Photo courtesy of Sysmex)

Developed Immunoassay Predicts Benefits of Anti-PD-1 Therapy in NSCLC

Lung cancer is the most common cause of cancer-related deaths worldwide. However, current targeted therapies and immunotherapies have gradually improved patient survival. Anti-programmed cell death-1 (PD-1) antibodies (Abs) are key drugs in non-small-cell lung cancer treatment; however, clinical benefits with anti-PD-1 monotherapy are limited. More...
12 May 2021
Image: Schematic of the imaging of pathological tissue 3D structure by combining optical diffraction tomography and automated stitching (Photo courtesy of Korea Advanced Institute of Science and Technology)

Holographic Histopathology Enables Fast, Precise Diagnostics

Microscopic assessment of biopsied and resected tissues is central to understanding the underlying pathophysiology and clinical states of many patients. Because most microscopic specimens are translucent to visible light, conventional histological methods achieve image contrast using exogenous labels. More...
10 May 2021
Image: The Hamamatsu Photonics Nanozoomer 1 Digital Slide Scanner (Photo courtesy of University of Adelaide)

Genetic Background and Clinicopathologic Features Established for Adult-Onset Nephronophthisis

Nephronophthisis (NPH) is a genetic disorder of the kidneys which mainly affects children. It is classified as a medullary cystic kidney disease. The disorder is inherited in an autosomal recessive fashion and, although rare, is the most common genetic cause of childhood kidney failure. More...
06 May 2021
Image: Histology showing pathological and immunopathological findings from a spinal cord lesion from a 52-year-old woman who died from active neuromyelitis optica associated with a longitudinally extensive spinal cord lesion extending from C3 to T8 (Photo courtesy of CHU de Strasbourg)

African-American MS Patients Experience More Rapid B-Cell Repopulation

Multiple sclerosis (MS) is a potentially disabling disease of the brain and spinal cord (central nervous system). In MS, the immune system attacks the protective sheath (myelin) that covers nerve fibers and causes communication problems between the brain and the rest of the body. More...
06 May 2021
Image: The Oncotype DX Genomic Prostate Score (GPS) test is a strong independent predictor of prostate cancer-specific death and disease progression (metastases) at 10 years in men with localized prostate cancer (Photo courtesy of Genomic Health)

GPS Assay Associated with Long-Term Prostate Cancer Outcomes

Long-term cancer outcomes are an important consideration when deciding between active surveillance (AS) and immediate treatment for newly diagnosed prostate cancer. Multiple prospective AS studies that predominantly include patients at the lowest risk of progression have demonstrated a low risk of distant metastasis (DM) and prostate cancer–specific mortality (PCSM) with extended follow-up. More...
03 May 2021
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The Pathology channel details advances in the field of Surgical Pathology and all its subspecialties, including Cytopathology and its subspecialties.

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