Features Partner Sites Information LinkXpress hp
Sign In
Advertise with Us
LGC Clinical Diagnostics

Download Mobile App




Diagnostic Performance of Blood Counts Compared

By LabMedica International staff writers
Posted on 17 Oct 2017
The use of point-of-care testing is increasing, however many hematology analyzers can only determine granulocyte count without further differentiation into neutrophils, eosinophils and basophils.

The technology of morphological assessment and counting of blood cells has advanced over recent decades, particularly in the white cell lineage, with concomitant benefits in relation to diagnosis, prognosis and management of inflammatory and malignant conditions. The full range of measurements is available on modern automated laboratory analyzers.

Laboratory scientists at the Leeds Institute of Health Science (Leeds, UK) conducted an analysis on a pseudonymised, retrospective database containing peripheral venous blood sample results between 1 January 2004 and 1 September 2013 from 21,020 patients, all of whom had received chemotherapy treatment. Blood counts were measured from EDTA venous whole blood samples obtained for the purposes of routine clinical care, and taken at any time in relation to chemotherapy delivery.

All samples were submitted for a full blood count analysis, including a five-part differential on a Siemens ADVIA 120 analyzer (Siemens Healthcare Diagnostics, Erlangen, Germany) until August 2004 and subsequently on the Siemens ADVIA 2120 analyzer; both instruments employ the same method principles. Data of interest included the eosinophil, basophil and neutrophil counts, with the sum of these three parameters being taken as the granulocyte count and lymphocyte and monocyte results were also extracted for analysis.

The team found that granulocyte to neutrophil count correlation was 0.997. The accuracy for classification into neutropenia grades using the derived equivalent granulocyte count ranges was 96.4%. Identification of results with a neutrophil count less than 1.5×109 cells/L using an equivalent granulocyte count of less than 1.69×109 cells/L resulted in sensitivity, specificity, positive and negative predictive values of 98.0%, 99.5%, 97.8% and 99.5%, respectively.

The authors concluded that their results describe the relationship between granulocyte and neutrophil counts, measured on a laboratory analyzer, in a large population of patients with malignancies and receiving anti-cancer therapies. However, this relationship must be established using a point of care testing system with a three-part differential count before considering the possibility that a granulocyte count can guide clinical decisions in the absence of a definitive neutrophil count, to reduce the frequency and severity of neutropenic complications in patients receiving cancer treatments. The study was published on October 4, 2017, in the journal Practical Laboratory Medicine.


Gold Member
Flocked Fiber Swabs
Puritan® Patented HydraFlock®
Verification Panels for Assay Development & QC
Seroconversion Panels
New
Anti-HHV-6 IgM Assay
anti-HHV-6 IgM ELISA (semiquant.)
New
Mycoplasma Pneumoniae Virus Test
Mycoplasma Pneumoniae Virus Detection Kit
Read the full article by registering today, it's FREE! It's Free!
Register now for FREE to LabMedica.com and get complete access to news and events that shape the world of Clinical Laboratory Medicine.
  • Free digital version edition of LabMedica International sent by email on regular basis
  • Free print version of LabMedica International magazine (available only outside USA and Canada).
  • Free and unlimited access to back issues of LabMedica International in digital format
  • Free LabMedica International Newsletter sent every week containing the latest news
  • Free breaking news sent via email
  • Free access to Events Calendar
  • Free access to LinkXpress new product services
  • REGISTRATION IS FREE AND EASY!
Click here to Register








Channels

Molecular Diagnostics

view channel
Image: Researcher Kanta Horie places a sample in a mass spectrometer that measures protein levels in blood plasma and other fluids (Photo courtesy of WashU Medicine)

Highly Accurate Blood Test Diagnoses Alzheimer’s and Measures Dementia Progression

Several blood tests are currently available to assist doctors in diagnosing Alzheimer's disease in individuals experiencing cognitive symptoms. However, these tests do not provide insights into the clinical... Read more

Immunology

view channel
Image: The findings were based on patients from the ADAURA clinical trial of the targeted therapy osimertinib for patients with NSCLC with EGFR-activated mutations (Photo courtesy of YSM Multimedia Team)

Post-Treatment Blood Test Could Inform Future Cancer Therapy Decisions

In the ongoing advancement of personalized medicine, a new study has provided evidence supporting the use of a tool that detects cancer-derived molecules in the blood of lung cancer patients years after... Read more

Microbiology

view channel
Image: Schematic representation illustrating the key findings of the study (Photo courtesy of UNIST)

Breakthrough Diagnostic Technology Identifies Bacterial Infections with Almost 100% Accuracy within Three Hours

Rapid and precise identification of pathogenic microbes in patient samples is essential for the effective treatment of acute infectious diseases, such as sepsis. The fluorescence in situ hybridization... Read more
Copyright © 2000-2025 Globetech Media. All rights reserved.