We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress hp
Sign In
Advertise with Us
LGC Clinical Diagnostics

Download Mobile App




Hematological Parameters Detect Patients with Acute VTE

By LabMedica International staff writers
Posted on 08 Oct 2019
Print article
Image: The Gen-S hematology analyzer (Photo courtesy of Beckman Coulter).
Image: The Gen-S hematology analyzer (Photo courtesy of Beckman Coulter).
Venous thromboembolism (VTE) encompasses deep venous thrombosis (DVT) and pulmonary embolism (PE). VTE causes cardiovascular death and disability and the risk of PE‐associated mortality and morbidity extends far beyond the acute phase of the disease.

Diagnosis of VTE is often difficult, and point score criteria help to estimate the clinical likelihood of DVT and PE. Patients with a low‐to‐moderate likelihood of DVT or PE should undergo initial diagnostic evaluation with D‐dimer testing alone without obligatory imaging tests; however, the D‐dimer assay is not specific.

Internal Medicine Scientists at Ziv Medical Center (Safed, Israel) and colleagues carried out a retrospective cohort study which aimed to examine the association and correlation between VTE and various new inflammatory markers taken from medical records of 272 patients admitted with VTE and 55 patients without VTE were used as control group.

Red blood cell distribution width (RDW), mean platelet volume (MPV), neutrophil‐lymphocyte ratio (NLR), and platelet‐lymphocyte ratio (PLR) were obtained and calculated from the complete blood count which executed in the hematology unit with Beckman Coulter Gen‐S system device. NLR was defined as the absolute neutrophil count divided by the absolute lymphocyte count. PLR was defined as the absolute platelet count divided by the absolute lymphocyte count. RDW and MPV were obtained from the results of the complete blood count (CBC).

The team reported that patients with VTE were older than controls (62 ± 18.9 versus 55.4 ± 15.1 years), respectively and female gender was predominant in the two groups. In the study group, 178/272 (66%) had DVT, 84/272 (31%) had pulmonary embolism (PE), and the rest had DVT and PE. NLR, MPV, and PLR were found to be significantly elevated in acute VTE compared to control. A ROC curve analysis of NLR and MPV for predicting acute VTE was performed, which found a cut‐off value of 5.3 for NLR, an area under curve of (0.67 [0.60‐0.75]), with a sensitivity of 69% and specificity of 57%, and a cut‐off value of 8.6 for MPV, an area under curve of (0.61 [0.53‐0.68]), with a sensitivity of 52% and specificity of 67%.

The authors concluded that the neutrophil‐lymphocyte ratio and MPV could be beneficial predictors for the early detection of potential acute VTE. The study was published on September 11, 2019, in the Journal of Clinical Laboratory Analysis.

Related Links:
Ziv Medical Center

Gold Member
Flocked Fiber Swabs
Puritan® Patented HydraFlock®
Verification Panels for Assay Development & QC
Seroconversion Panels
New
Toxoplasma Gondii Immunoassay
Toxo IgM AccuBind ELISA Kit
New
Respiratory QC Panel
Assayed Respiratory Control Panel

Print article

Channels

Molecular Diagnostics

view channel
Image: Researcher Kanta Horie places a sample in a mass spectrometer that measures protein levels in blood plasma and other fluids (Photo courtesy of WashU Medicine)

Highly Accurate Blood Test Diagnoses Alzheimer’s and Measures Dementia Progression

Several blood tests are currently available to assist doctors in diagnosing Alzheimer's disease in individuals experiencing cognitive symptoms. However, these tests do not provide insights into the clinical... Read more

Immunology

view channel
Image: The findings were based on patients from the ADAURA clinical trial of the targeted therapy osimertinib for patients with NSCLC with EGFR-activated mutations (Photo courtesy of YSM Multimedia Team)

Post-Treatment Blood Test Could Inform Future Cancer Therapy Decisions

In the ongoing advancement of personalized medicine, a new study has provided evidence supporting the use of a tool that detects cancer-derived molecules in the blood of lung cancer patients years after... Read more

Microbiology

view channel
Image: Schematic representation illustrating the key findings of the study (Photo courtesy of UNIST)

Breakthrough Diagnostic Technology Identifies Bacterial Infections with Almost 100% Accuracy within Three Hours

Rapid and precise identification of pathogenic microbes in patient samples is essential for the effective treatment of acute infectious diseases, such as sepsis. The fluorescence in situ hybridization... Read more
Copyright © 2000-2025 Globetech Media. All rights reserved.