We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress hp
Sign In
Advertise with Us
LGC Clinical Diagnostics

HAEMONETICS

Haemonetics Corporation’s comprehensive portfolio of devices, information management, and consulting services offers ... read more Featured Products: More products

Download Mobile App




Coagulopathy Testing Linked to Better COVID-19 Outcomes

By LabMedica International staff writers
Posted on 19 Jan 2021
Print article
Image: The TEG 5000 Thrombelastograph Hemostasis Analyzer system is a diagnostic instrument that provides comprehensive whole blood hemostasis testing that can help assess bleeding and thrombotic risks, and also monitor antithrombotic therapies (Photo courtesy of Haemonetics).
Image: The TEG 5000 Thrombelastograph Hemostasis Analyzer system is a diagnostic instrument that provides comprehensive whole blood hemostasis testing that can help assess bleeding and thrombotic risks, and also monitor antithrombotic therapies (Photo courtesy of Haemonetics).
Significant infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may lead to development of coagulopathy, most typically a hypercoagulable state. In addition to thrombotic conditions, coronavirus disease 2019 (COVID-19) patients may develop hemorrhagic complications, which have been under recognized or inadequately emphasized in prior studies.

Thromboelastography (TEG), being a whole blood assay, is a more inclusive technology that evaluates the overall contribution of blood cells, platelets, and plasma during clot formation by mimicking in vivo coagulation processes. TEG can measure profound hemostatic derangements, and it identifies key dysfunctional components, from the initiation phase of blood clotting to the fibrinolysis phase.

A multidisciplinary team working with the Memorial Regional Hospital (Hollywood, FL, USA) and the hospital-based Thromboelastography Task Force (TTF) prospectively followed 100 patients meeting certain criteria to assist with the application and interpretation of initial and on-going TEG findings over a five month period. Included in the TEG was platelet mapping (TEG-PM). Among the 100 patients studied, ages ranged from 32 to 91 years, and 67% were male, 46.5% African American, 29.3% Hispanic.

For identification of Coagulopathy Based on TEG-PM, the TTF used the processing device TEG 5000 Thrombelastograph Hemostasis Analyzer (Haemonetics, Boston, MA, USA), with PM employed to specifically assess activation of the platelet’s cyclooxygenase 1 (maximum amplitude [MA]-arachidonic acid [AA]) and P2Y12 pathways (MA-adenosine diphosphate [ADP]). Follow-up TEG-PM assays were clinician ordered and collected every 48–72 hours when possible.

The scientists reported that among 100 COVID-19 patients who got TEG-PM upon admission at a center where it was routine for hypoxemic patients in the emergency department, death was 7.7-fold more common among those whose treatment did not follow the TEG-guided treatment algorithm (17 of 28 [60.7%] versus four of 72 [5.6%]. Inflammatory markers were associated with clinical deterioration, pulmonary failure (PF), acute kidney injury (AKI), and death. D-dimer was significantly higher in non-Algorithm-Guided (AG) patients, but ferritin and C-reactive protein (CRP) were not significantly different between the two groups. For non-survivors, irreversible thrombocytopenia (< 100,000/µL) was an unmistakable sign of deterioration/death.

The authors concluded that COVID-19 coagulopathy has a multifaceted, chameleon spectrum of coagulopathy with platelet aberrations often playing a large role. Therefore, they recommended that patient-tailored diagnosis/characterization and treatment of COVID-19 coagulopathy should be based on a standardized algorithm employing TEG-PM. The study was published in the December 2020 issue of the journal Critical Care Explorations.

Related Links:
Memorial Regional Hospital
Haemonetics


Gold Member
Chagas Disease Test
CHAGAS Cassette
Verification Panels for Assay Development & QC
Seroconversion Panels
New
Malaria Test
STANDARD Q Malaria P.f/Pan Ag
New
Coagulation Analyzer
CS-2400

Print article

Channels

Molecular Diagnostics

view channel
Image: Researcher Kanta Horie places a sample in a mass spectrometer that measures protein levels in blood plasma and other fluids (Photo courtesy of WashU Medicine)

Highly Accurate Blood Test Diagnoses Alzheimer’s and Measures Dementia Progression

Several blood tests are currently available to assist doctors in diagnosing Alzheimer's disease in individuals experiencing cognitive symptoms. However, these tests do not provide insights into the clinical... Read more

Immunology

view channel
Image: The findings were based on patients from the ADAURA clinical trial of the targeted therapy osimertinib for patients with NSCLC with EGFR-activated mutations (Photo courtesy of YSM Multimedia Team)

Post-Treatment Blood Test Could Inform Future Cancer Therapy Decisions

In the ongoing advancement of personalized medicine, a new study has provided evidence supporting the use of a tool that detects cancer-derived molecules in the blood of lung cancer patients years after... Read more

Microbiology

view channel
Image: Schematic representation illustrating the key findings of the study (Photo courtesy of UNIST)

Breakthrough Diagnostic Technology Identifies Bacterial Infections with Almost 100% Accuracy within Three Hours

Rapid and precise identification of pathogenic microbes in patient samples is essential for the effective treatment of acute infectious diseases, such as sepsis. The fluorescence in situ hybridization... Read more
Copyright © 2000-2025 Globetech Media. All rights reserved.