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BioResearch

Image: A scanning electron micrograph (SEM) of a human a T-cell from the immune system of a healthy donor (Photo courtesy of the [U.S.] National Institutes of Health).

Vaccine Induces Protective Immune Response in Mouse Model

Vaccination of mice with a peptide derived from the apoB protein component of low density lipoprotein (LDL) stimulated increased production of regulatory T-cells (Tregs) and reduction in number and size of atherosclerotic lesions. More...
25 Apr 2018
Image: Gene-editing technology is moving closer to becoming a therapeutic reality due to the introduction of artificial guide RNAs that increase the precision of the technique (Photo courtesy of the University of Alberta).

Artificial RNAs Increase Precision of Gene-Editing System

Incorporation of next-generation bridged nucleic acids at specific locations in CRISPR-RNAs (crRNAs) broadly reduces off-target DNA cleavage by Cas9 - a major drawback slowing the development of genome editing clinical applications - in vitro and in cells by several orders of magnitude. More...
24 Apr 2018
Image: A photomicrograph showing fibrotic heart cells from a patient who had heart failure. The cells have an elaborate fibronectin matrix (shown in red), which causes fibrosis and heart damage (Photo courtesy of Cincinnati Children\'s Hospital Medical Center).

Inhibiting Fibronectin Polymerization Reduces Injury to Cardiac Muscle

Working with a mouse model of human heart disease, researchers showed that interfering with fibronectin (FN) polymerization or its genetic deletion in fibroblasts would attenuate cardiac myofibroblasts (MF), fibrosis, and improve cardiac function following heart attack related injury. More...
24 Apr 2018
Image: Organoids created from the bladder cancers of patients mimic the characteristics of each patient\'s tumor and may be used in the future to identify the best treatment for each patient (Photo courtesy of Columbia University Medical Center).

Bladder Cancer Organoids May Lead to Treatment Breakthrough

Cancer researchers have established a "bio-bank" of patient-derived organoid lines that recapitulates the histopathological and molecular diversity of human bladder cancer. More...
19 Apr 2018
Image: A micrograph of the West Nile virus (shown in yellow) (Photo courtesy of Wikimedia Commons).

Vaccine Cures and Protects against West Nile Virus

Treatment with a novel siRNA-based vaccine offered efficient late-stage therapy and facilitated development of natural long-term immunity against West Nile virus in a mouse model system. More...
18 Apr 2018

Finnish Study Describes Activators of SIRT6 Gene

A team of Finnish researchers conducted a study to evaluate the differences in chemical features between inhibitors and activators of the cancer-related SIRT6 gene. More...
17 Apr 2018
Image: Calcium phosphate mineralization occurs in both extra- and intrafibrillar spaces of collagen (left and right images, respectively). The confined collagen structure contributes to reducing the thermodynamic energy barrier to intrafibrillar nucleation for bone mineralization (Photo courtesy of Washington University).

Nano-Imaging Reveals Links to Regulation of Bone Mineralization

A team of bioengineers applied a hi-tech nano-imagining technique to determine the mechanisms involved in the initialization and regulation of the process of bone mineralization. More...
16 Apr 2018
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BioResearch brings the latest research news on the genome, proteome, metabolome, on drug discovery, and therapeutics. Biotech researchers, lab administrators, technologists, drug manufacturers, and suppliers can find the latest research news and information related to their fields of endeavor here.
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