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Molecular Diagnostics

Image: Proteogenomic Characterization of Endometrial Carcinoma (Photo courtesy of the Clinical Proteomic Tumor Analysis Consortium).

Proteogenomic Characterization of Endometrial Carcinoma Analyzed

 Endometrial cancer is a cancer that arises from the endometrium which is the lining of the uterus or womb. It is the result of the abnormal growth of cells that have the ability to invade or spread to other parts of the body. More...
24 Feb 2020
Image: The level of uric acid in saliva is a good indicator of body fat percentage in a study designed to identify reliable biomarkers that can be used to develop quick non-invasive tests for early detection of chronic diseases ((Photo courtesy of Dr. Paula Midori Castelo, Federal University of São Paulo)

Uric Acid in Saliva Is a Biomarker for Body Fat Accumulation in Adolescents

 The noninvasive measurement of uric acid in saliva has been shown to be an important marker of body fat accumulation in adolescents, which demonstrates the clinical relevance of saliva for detection of early metabolic changes and monitoring of nutritional status. More...
24 Feb 2020
Image: Ceramide structure: R represents the alkyl portion of a fatty acid (Photo courtesy of Wikimedia Commons)

Ratio of Serum Very-long-chain to Long-chain Ceramides Is Predictive of Dementia Risk

 Results obtained by a large community-based study showed that the ratio of very long‐chain to long‐chain ceramides in the blood was associated with risk of developing various types of dementia including Alzheimer's disease (AD). More...
24 Feb 2020
Image: The VisuLize Factor XI ELISA Kit is an Enzyme Immunoassay for the quantitative determination of Factor XI Antigen in human plasma samples using the double antibody enzyme linked immuno-sorbent assay (ELISA) (Photo courtesy of Affinity Biologicals, Inc).

Factor IX Inhibitor Incidence in Pediatric Hemophilia B Examined

 Hemophilia B is a blood clotting disorder causing easy bruising and bleeding due to an inherited mutation of the gene for factor IX, and resulting in a deficiency of factor IX. It is less common than factor VIII deficiency (hemophilia A). More...
20 Feb 2020
Image: Normal electrocardiogram (ECG) and an ECG showing QT interval prolongation (long QT syndrome). The P wave represents atrial depolarization; the QRS complex, ventricular depolarization; and the T wave, ventricular repolarization. The QT interval is measured from the beginning of the QRS complex to the return of the T wave to the isoelectric line (Photo courtesy of Mayo Clinic).

Several Genes Linked to Long QT Syndrome Reappraised

 Long QT syndrome (LQTS) is the first described and most common inherited arrhythmia. Over the last 25 years, multiple genes have been reported to cause this condition and are routinely tested in patients. More...
20 Feb 2020
Image: Copy number variants (CNVs) detection directly by UW-OncoPlex sequencing; depicted are examples from a melanoma and colon cancer sample (Photo courtesy of Noah G. Hoffman, MD, PhD).

Modular Targeted Capture Assay Detects Clinically Significant Oncology Alterations

 The rapid discovery of clinically significant genetic variants has translated to next-generation sequencing assays becoming out-of-date by the time they are designed, validated, and implemented. More...
19 Feb 2020
Image: Photomicrograph of a lymph node with almost complete replacement by metastatic melanoma (Photo courtesy of Wikimedia Commons)

Assessment of Circulating Tumor Cells Identifyies Stage III Melanoma Patients at Risk for Relapse

 Circulating tumor cells found in liquid biopsy specimens have been shown to be useful biomarkers for identifying stage III melanoma patients at risk for relapse. More...
19 Feb 2020
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Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.
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