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Pathology

Image: The HM-JACKarc analytical system is a compact bench top system that uses Integrated Sphere Latex Turbidimetry to measure fecal hemoglobin concentration using a highly sensitive latex reagent coated with polyclonal antibodies to human hemoglobin (Photo courtesy of Hitachi Chemical Diagnostics Systems).

Fecal Immunochemical Test Assessed in Suspected Colorectal Cancer

Colorectal cancer (CRC), also known as bowel cancer, colon cancer, or rectal cancer, is the development of cancer from the colon or rectum (parts of the large intestine). Signs and symptoms may include blood in the stool, a change in bowel movements, weight loss, and fatigue. More...
05 Nov 2020
Image: A neural stem cell model of sporadic congenital hydrocephalus (Photo courtesy of Yale University School of Medicine).

Genetic Alterations Associated with Sporadic Congenital Hydrocephalus

Congenital hydrocephalus (CH), characterized by enlarged brain ventricles, is considered a disease of excessive cerebrospinal fluid (CSF) accumulation and thereby treated with neurosurgical CSF diversion with high morbidity and failure rates. More...
02 Nov 2020
Image: A sample collection kit for the expanded Multi-Cancer 83-gene comprehensive panel that increases diagnostic yield. Germline testing after tumor sequencing uncovers clinically actionable variants (Photo courtesy of Invitae).

Germline Testing After Tumor Sequencing Uncovers Clinically Actionable Variants

Genetic counseling and germline testing are recommended for patients with cancer who have suspected hereditary disease based on each patient’s presentation and family history. Separately, tumor DNA sequencing is increasingly used, most often in patients with advanced disease. More...
27 Oct 2020
Image: Circulating tumor cells (CTCs) are cancer cells that are released and disseminated into the bloodstream and lymphatic system. CTC cultures were successfully propagated from breast epithelial cells (Photo courtesy of Menarini Silicon Biosystems).

Novel CTC Culture Method Developed to Study Metastatic Cancer

Cancer metastasis is responsible for most cancer-associated death. During metastasis, cells that escape the primary tumor into the circulatory system are known as circulating tumor cells (CTCs). More...
26 Oct 2020
Image: Photomicrograph of histology of a Ewing sarcoma in lung. The PAS stain highlights glycogen and the staining was negative with a PAS diastase stain (Photo courtesy of Nephron).

Comprehensive Molecular Profiling Matches Pediatric Patients to Therapies

A major challenge of using a comprehensive profiling approach for precision medicine is separating pathogenic from non-pathogenic molecular changes within a tumor. More...
22 Oct 2020
Image: The HiSeq XTen human whole- genome sequencing system (Photo courtesy of Illumina).

Urine-Based Liquid Biopsy Test Detects Urothelial Carcinoma

Urine cytology, which is widely used to screen for bladder cancer, has high specificity but lacks sensitivity, especially for low-grade cancers. Cystoscopy, while more accurate than cytology, is an invasive procedure with added costs and potential complications for the patient. More...
22 Oct 2020
Image: Breath test developed for head and neck cancer diagnosis used a selected ion flow-tube mass spectrometer (Photo courtesy of Syft Technologies).

Breath Test Developed for Head and Neck Cancer Diagnosis

Breath testing is a noninvasive way to help doctors diagnose a number of conditions. By analyzing the breath, the physicians can measure the amount of certain gases, allowing doctors to arrive at a diagnosis quickly and accurately. More...
20 Oct 2020
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The Pathology channel details advances in the field of Surgical Pathology and all its subspecialties, including Cytopathology and its subspecialties.

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