We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress hp
Sign In
Advertise with Us
LGC Clinical Diagnostics

Download Mobile App




Liquid-Based Cytology Is as Effective as Conventional Smears

By LabMedica International staff writers
Posted on 08 Nov 2010
Print article
Cervical cytology specimens are used to check abnormalities and are regularly used as a prophylactic test in gynecological examinations.

The routine Papanicolau (Pap) test has been compared to liquid based cytology to evaluate the efficiency and effectiveness of systems based on cytocentrifugation. The sensitivity and specificity of the liquid-based gynecological system was assessed.

In a study carried out at Vilnius University, (Vilnius, Lithuania), 2,945 women referred to prophylactic check-up were enrolled. Split sample design was used in 1,500 women and residual cervical cytology specimen from all these cases was placed in fluid for cytocentrifugation preparation after performing conventional smears. The centrifugation was performed in a low speed centrifugal force device called the Shandon PapSpin. The direct-to-vial study was carried out in another cohort of 1,445 women in whom the entire cervical material was investigated using only the PapSpin technique.

In the split sample group, conventional smears showed a higher proportion of atypical cells undetermined significance (ASC-US): 2.1% compared to 0.7% in the PapSpin samples. A higher proportion of unsatisfactory samples were found in the conventional smear group1.7% compared to 0.4% of cases in the device group. In the split sample group, the sensitivity of the conventional and PapSpin tests was 68.7% versus 78.1%, and the specificity 93.8% versus 91.8%, respectively. In the direct to vial group, PapSpin sensitivity was 75.9% and specificity 96.5%. The Shandon PapSpin is manufactured by Thermo Shandon (Pittsburgh, PA, USA).

The PapSpin method offers several advantages such as the opportunity to prepare duplicate slides, option for Human Papilloma Virus (HPV) DNA testing and cell block preparations from residual material. Microscopic evaluation of thinner cell preparations is less time consuming than the conventional Pap smears. The study was published online in March 2010, in Cytology Journal.

Related Links:
Vilnius University
Thermo Shandon


New
Gold Member
Rotavirus Test
Rotavirus Test - 30003 – 30073
Verification Panels for Assay Development & QC
Seroconversion Panels
New
Multi-Function Pipetting Platform
apricot PP5
New
Toxoplasma Gondii Immunoassay
Toxo IgM AccuBind ELISA Kit

Print article

Channels

Molecular Diagnostics

view channel
Image: Researcher Kanta Horie places a sample in a mass spectrometer that measures protein levels in blood plasma and other fluids (Photo courtesy of WashU Medicine)

Highly Accurate Blood Test Diagnoses Alzheimer’s and Measures Dementia Progression

Several blood tests are currently available to assist doctors in diagnosing Alzheimer's disease in individuals experiencing cognitive symptoms. However, these tests do not provide insights into the clinical... Read more

Immunology

view channel
Image: The findings were based on patients from the ADAURA clinical trial of the targeted therapy osimertinib for patients with NSCLC with EGFR-activated mutations (Photo courtesy of YSM Multimedia Team)

Post-Treatment Blood Test Could Inform Future Cancer Therapy Decisions

In the ongoing advancement of personalized medicine, a new study has provided evidence supporting the use of a tool that detects cancer-derived molecules in the blood of lung cancer patients years after... Read more

Microbiology

view channel
Image: Schematic representation illustrating the key findings of the study (Photo courtesy of UNIST)

Breakthrough Diagnostic Technology Identifies Bacterial Infections with Almost 100% Accuracy within Three Hours

Rapid and precise identification of pathogenic microbes in patient samples is essential for the effective treatment of acute infectious diseases, such as sepsis. The fluorescence in situ hybridization... Read more
Copyright © 2000-2025 Globetech Media. All rights reserved.