We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress hp
Sign In
Advertise with Us
LGC Clinical Diagnostics

Download Mobile App




Blood Test Could Predict Outcomes in Emergency Department and Hospital Admissions

By LabMedica International staff writers
Posted on 14 Aug 2023
Print article
Image: A new study has linked part of CBC with risk of hospital admission and in-hospital mortality (Photo courtesy of Shutterstock)
Image: A new study has linked part of CBC with risk of hospital admission and in-hospital mortality (Photo courtesy of Shutterstock)

Red blood cell distribution width (RDW), an integral component of the complete blood count (CBC) panel, measures the variation in red blood cell size. Increased RDW levels have demonstrated a relation to unfavorable patient outcomes across a range of diseases, spanning from heart attacks to COVID-19 pneumonia. Recent research has identified RDW as a generalizable biomarker for emergency department (ED) acuity. However, there have been few studies to examine the prognostic value of RDW within the ED setting. Previous studies have mainly focused on specific diseases like acute coronary syndrome, deep vein thrombosis, and sepsis, often employing limited sample sizes ranging from hundreds to thousands of patients. Now, a new study using a large dataset of ED visits has revealed that higher RDW value in the ED is correlated to hospital admission and, in individuals admitted to the hospital, in-hospital mortality.

Researchers in the Department of Emergency Medicine at UCLA David Geffen School of Medicine (Los Angeles, CA, USA) conducted a retrospective analysis of over 200,000 adult ED visits with CBC results between the period March 2013 and February 2022. The study’s key objective was to investigate the correlation between initial RDW measurements obtained during ED visits and two crucial outcomes: hospital admission and in-hospital mortality. The study revealed that elevated RDW levels were notably prevalent in visits culminating in hospital admission. Moreover, among admitted patients, those necessitating intensive care unit (ICU) care or experiencing in-hospital mortality exhibited even higher RDW values.

An RDW value of more than 16 demonstrated a specificity of 90% for predicting hospital admission, while an RDW value exceeding 18.5 demonstrated 90% specificity for predicting in-hospital mortality. These findings are in line with prior studies that have linked heightened RDW levels to higher mortality risks in conditions such as myocardial infarction, pulmonary embolism, heart failure, sepsis, and COVID-19. However, the latest study establishes a relation between RDW and overall hospital admissions as well as in-hospital mortality across all-cause adult ED visits. According to the researchers, while elevated RDW alone might not possess the sensitivity required for a comprehensive diagnostic tool, combining it with other clinical data could substantially enhance clinicians' capacity to predict hospital admissions and identify patients at heightened risk of in-hospital mortality.

Related Links:
UCLA David Geffen School of Medicine

Gold Member
Pharmacogenetics Panel
VeriDose Core Panel v2.0
New
Gold Member
Rotavirus Test
Rotavirus Test - 30003 – 30073
New
Immunofluorescence Analyzer
MPQuanti
New
Bordetella Pertussis Molecular Assay
Alethia Pertussis

Print article

Channels

Immunology

view channel
Image: The findings were based on patients from the ADAURA clinical trial of the targeted therapy osimertinib for patients with NSCLC with EGFR-activated mutations (Photo courtesy of YSM Multimedia Team)

Post-Treatment Blood Test Could Inform Future Cancer Therapy Decisions

In the ongoing advancement of personalized medicine, a new study has provided evidence supporting the use of a tool that detects cancer-derived molecules in the blood of lung cancer patients years after... Read more

Pathology

view channel
Image: Microscopic images showing healthy villi on the left and diseased villi on the right (Photo courtesy of Florian Jaeckle/University of Cambridge)

Powerful AI Tool Diagnoses Coeliac Disease from Biopsy Images with Over 97% Accuracy

Coeliac disease is an autoimmune disorder triggered by the consumption of gluten, causing symptoms such as stomach cramps, diarrhea, skin rashes, weight loss, fatigue, and anemia. Due to the wide variation... Read more
Copyright © 2000-2025 Globetech Media. All rights reserved.