We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress hp
Sign In
Advertise with Us
LGC Clinical Diagnostics

Download Mobile App




Cord Blood IgE Levels Tied To Allergy, Asthma Rates

By LabMedica International staff writers
Posted on 22 Aug 2022
Print article
Image: The BioIC Allergen Specific-IgE Detection Kit-AD 40 panel (Photo courtesy of Agnitio Science and Technology).
Image: The BioIC Allergen Specific-IgE Detection Kit-AD 40 panel (Photo courtesy of Agnitio Science and Technology).

The rising prevalence of allergic diseases worldwide represents an important health problem. Early identification of children at high risk of allergic diseases could be helpful for physicians to recommend preventive measures and apply early interventions.

Cord blood immunoglobulin E (IgE) has been considered as a potential marker for years due to its predictability for allergic diseases, but the results are controversial. Several studies have reported that elevated cord blood IgE may predict allergic diseases and/or allergic sensitization in childhood, whereas other studies failed to find it as a good predictor.

Immunologists at the Chang Gung Memorial Hospital (Taoyuan, Taiwan) included 566 children (321 boys; mean age, 6.5 ± 0.4 years) in a prospective population-based cohort study designed to longitudinally investigate the effects of early-life environmental exposures and genetic predisposition on childhood allergic outcomes. Blood samples were drawn for subsequent measurement of serum total and allergen-specific IgE. Measurements of nitric oxide (FeNO) and pulmonary function were performed in standard procedures.

Serum total IgE was determined by ImmunoCAP (Phadia, Uppsala, Sweden). Allergic sensitization was defined as a positive Phadia Phadiatop Infant test result (≧0.35 PAU/L), detecting allergen-specific IgE against a mix of common inhalant and food allergens. Serum levels of allergen-specific IgE were measured using an automated microfluidic-based multiplexed immunoassay system, the BioIC Allergen-specific IgE Detection Kit- AD40 Panel; Agnitio Science and Technology, Hsinchu, Taiwan). FeNO measurement was performed by chemiluminescence analyzer (CLD 88sp NO analyzer, Ecomedics, Duernten, Switzerland).

The investigators reported that cord blood IgE levels were significantly associated with FeNO levels and serum total IgE levels. Cord blood IgE levels were positively associated with allergic sensitization (adjusted odds ratio [AOR] = 2.22). Specifically, they found significant associations between elevated levels of IgE in cord blood and higher likelihoods for sensitization to house dust mites (Dermatophagoides pteronyssinus and D. farina), dog dander, egg yolk, garlic and baker’s yeast.

Subjects with cord blood IgE ≥0.24 kU/L (the optimal cutoff) were significantly associated with an increased risk of allergic sensitization (AOR = 2.63,) and asthma (AOR = 2.35) than those with cord blood IgE <0.24 kU/L. Subjects with cord blood IgE ≥0.24 kU/L had significantly higher FeNO levels than those with cord blood IgE <0.24 kU/L. There were no significant associations between cord blood IgE levels and pulmonary function parameters.

The authors concluded that that cord blood IgE ≥0.24 kU/L predicts allergic sensitization, FeNO elevation, and asthma among Asian schoolchildren. Specifically, cord blood IgE levels ≥0.24 kU/L was associated with a 2.6-fold increased risk of allergic sensitization, particularly sensitization to mites, animals, and foods, at six years of age. This study suggests that cord blood IgE levels would be useful for early identification of newborns at risk of subsequent allergic sensitization and allergic airway inflammation at school age. The study was published on August 1, 2022 in the journal Pediatric Allergy and Immunology.

Related Links:

Chang Gung Memorial Hospital
Phadia
Agnitio Science and Technology
Ecomedics

Gold Member
Pharmacogenetics Panel
VeriDose Core Panel v2.0
Verification Panels for Assay Development & QC
Seroconversion Panels
New
Respiratory Bacterial Panel
Real Respiratory Bacterial Panel 2
New
Bordetella Pertussis Molecular Assay
Alethia Pertussis

Print article

Channels

Clinical Chemistry

view channel
Image: The tiny clay-based materials can be customized for a range of medical applications (Photo courtesy of Angira Roy and Sam O’Keefe)

‘Brilliantly Luminous’ Nanoscale Chemical Tool to Improve Disease Detection

Thousands of commercially available glowing molecules known as fluorophores are commonly used in medical imaging, disease detection, biomarker tagging, and chemical analysis. They are also integral in... Read more

Microbiology

view channel
Image: The lab-in-tube assay could improve TB diagnoses in rural or resource-limited areas (Photo courtesy of Kenny Lass/Tulane University)

Handheld Device Delivers Low-Cost TB Results in Less Than One Hour

Tuberculosis (TB) remains the deadliest infectious disease globally, affecting an estimated 10 million people annually. In 2021, about 4.2 million TB cases went undiagnosed or unreported, mainly due to... Read more

Pathology

view channel
Image: The ready-to-use DUB enzyme assay kits accelerate routine DUB activity assays without compromising data quality (Photo courtesy of Adobe Stock)

Sensitive and Specific DUB Enzyme Assay Kits Require Minimal Setup Without Substrate Preparation

Ubiquitination and deubiquitination are two important physiological processes in the ubiquitin-proteasome system, responsible for protein degradation in cells. Deubiquitinating (DUB) enzymes contain around... Read more

Technology

view channel
Image: The HIV-1 self-testing chip will be capable of selectively detecting HIV in whole blood samples (Photo courtesy of Shutterstock)

Disposable Microchip Technology Could Selectively Detect HIV in Whole Blood Samples

As of the end of 2023, approximately 40 million people globally were living with HIV, and around 630,000 individuals died from AIDS-related illnesses that same year. Despite a substantial decline in deaths... Read more

Industry

view channel
Image: The collaboration aims to leverage Oxford Nanopore\'s sequencing platform and Cepheid\'s GeneXpert system to advance the field of sequencing for infectious diseases (Photo courtesy of Cepheid)

Cepheid and Oxford Nanopore Technologies Partner on Advancing Automated Sequencing-Based Solutions

Cepheid (Sunnyvale, CA, USA), a leading molecular diagnostics company, and Oxford Nanopore Technologies (Oxford, UK), the company behind a new generation of sequencing-based molecular analysis technologies,... Read more
Copyright © 2000-2025 Globetech Media. All rights reserved.