We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
INTEGRA BIOSCIENCES AG

Download Mobile App




Events

09 Apr 2024 - 12 Apr 2024
15 Apr 2024 - 17 Apr 2024
23 Apr 2024 - 26 Apr 2024

Microbiome Alterations Influence Lung Disease Prognosis

By LabMedica International staff writers
Posted on 16 Oct 2018
Print article
Image: A histopathology of interstitial lung disease showing acute injury with necrosis. Necrosis (N) is a harbinger of infection in an acutely ill patient. Infection always leads the differential diagnosis in this situation, even if special stains are negative (Photo courtesy of Professor K.O. Leslie).
Image: A histopathology of interstitial lung disease showing acute injury with necrosis. Necrosis (N) is a harbinger of infection in an acutely ill patient. Infection always leads the differential diagnosis in this situation, even if special stains are negative (Photo courtesy of Professor K.O. Leslie).
Interstitial lung disease (ILD), or diffuse parenchymal lung disease (DPLD), is a group of lung diseases affecting the interstitium, which is the tissue and space around the air sacs of the lungs.

ILD involves alveolar epithelium, pulmonary capillary endothelium, basement membrane, perivascular and perilymphatic tissues. It may occur when an injury to the lungs triggers an abnormal healing response. Alterations to the respiratory microbiome have been identified as a predisposing factor of interstitial lung diseases.

Physicians at the Beaumont Health System (Royal Oak, MI, USA) and their colleagues conducted a retrospective analysis of 472 patients with ILD who were admitted to a large tertiary care academic center from January 1, 2010, to December 31, 2016. Patient data were extracted from electronic records using billing codes for various ILD. The majority of the patients had either pulmonary fibrosis or sarcoidosis.

The team collected 170 respiratory cultures were collected from the study population. The majority of the respiratory isolates were gram-negative pathogens (39% Pseudomonas and 18% other gram-negative organisms); 27% were methicillin-resistant Staphylococcus aureus (MRSA). Patients infected with gram-negative organisms (other than Pseudomonas) and MRSA had the highest 30-day mortality (39% and 32% respectively) compared with lower mortality for those infected with Pseudomonas and other gram positive organisms (7% and 14% respectively).

Patients infected with gram-negative organisms other than Pseudomonas also had higher rates of vasopressin administration compared with those infected with other organisms. Rates of intensive care units (ICU) admission also differed according to organism that was cultured. These associations persisted even after adjustment for the other variables including type of ILD, age, gender, comorbid conditions and smoking history. There was no association between the use of immunosuppressant medications or antifibrotics and the development of resistant pathogens.

Hira Iftikhar, MD, MBBS, the lead author of the study, said, “The presence of gram-negative bacteria is a risk factor for adverse events. These bacteria could lead to a higher mortality rate, ICU admission and increased vasopressor use. A larger study should be conducted to establish the risk factors for the mortality in hospitalized ILD patients including results of respiratory cultures.” The study was presented at the annual meeting of Chest, held October 6-10, 2018, in San Antonio, TX, USA.

Related Links:
Beaumont Health System

Platinum Member
COVID-19 Rapid Test
OSOM COVID-19 Antigen Rapid Test
HLX
Anti-Cyclic Citrullinated Peptide Test
GPP-100 Anti-CCP Kit
New
Gold Member
Systemic Autoimmune Testing Assay
BioPlex 2200 ANA Screen with MDSS

Print article

Channels

Clinical Chemistry

view channel
Image: Reaching speeds up to 6,000 RPM, this centrifuge forms the basis for a new type of inexpensive, POC biomedical test (Photo courtesy of Duke University)

POC Biomedical Test Spins Water Droplet Using Sound Waves for Cancer Detection

Exosomes, tiny cellular bioparticles carrying a specific set of proteins, lipids, and genetic materials, play a crucial role in cell communication and hold promise for non-invasive diagnostics.... Read more

Molecular Diagnostics

view channel
Image: MOF materials efficiently enrich cfDNA and cfRNA in blood through simple operational process (Photo courtesy of Science China Press)

Blood Circulating Nucleic Acid Enrichment Technique Enables Non-Invasive Liver Cancer Diagnosis

The ability to diagnose diseases early can significantly enhance the effectiveness of clinical treatments and improve survival rates. One promising approach for non-invasive early diagnosis is the use... Read more

Hematology

view channel
Image: The low-cost portable device rapidly identifies chemotherapy patients at risk of sepsis (Photo courtesy of 52North Health)

POC Finger-Prick Blood Test Determines Risk of Neutropenic Sepsis in Patients Undergoing Chemotherapy

Neutropenia, a decrease in neutrophils (a type of white blood cell crucial for fighting infections), is a frequent side effect of certain cancer treatments. This condition elevates the risk of infections,... Read more

Pathology

view channel
Image: The OvaCis Rapid Test discriminates benign from malignant epithelial ovarian cysts (Photo courtesy of INEX)

Intra-Operative POC Device Distinguishes Between Benign and Malignant Ovarian Cysts within 15 Minutes

Ovarian cysts represent a significant health issue for women globally, with up to 10% experiencing this condition at some point in their lives. These cysts form when fluid collects within a thin membrane... Read more
Copyright © 2000-2024 Globetech Media. All rights reserved.