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BioResearch

Image: A sample of silicon dioxide (Photo courtesy of Wikimedia Commons).

Silicon Treatment Preserves Antibiotics and Vaccines for Years

A novel method for encasing molecules of biomedical interest such as antibodies and vaccines in silica "cages" stabilizes them against denaturing thermal treatment and long-term ambient-temperature storage, and subsequently enables them to be released into solution with their structure and function intact. More...
03 May 2017
Image: New research reveals that the potential of Penicillia fungi for production of novel antibiotics is far from exhausted. The isolation of novel bioactive compounds from these species represents a source of new antibiotics to fight infectious microorganisms (Photo courtesy of Jens Christian Nielsen, Chalmers University of Technology).

Researchers Reevaluate Fungi to Produce New Drugs

Despite being the source of the first clinically administered antibiotic (penicillin), which was isolated by Alexander Fleming in 1928, the Penicillium species of fungi (Penicillia) continues to fascinate drug developers. More...
02 May 2017
Image: Tangles of the brain protein tau are associated with neurological diseases such as Alzheimer\'s. Specific antibodies can capture tau in the blood, facilitating efforts to measure levels of the damaging protein and paving the way toward a noninvasive test for tau (Photo courtesy of Sara Moser).

Anti-Tau Antibody May Facilitate New Diagnostic Procedures

The novel use of an antibody that specifically recognizes the tau protein may pave the way for development of a method to quantitate this protein, which has been linked to several debilitating neurological disorders, in samples of blood or plasma. More...
01 May 2017
Image: Neisseria gonorrhoeae infection in human endocervical tissue is visualized by immunofluorescence microscopy. Bacterial (red) colonization causes columnar endocervical epithelial cells to shed and lose the barrier function, which allows bacteria to enter the endocervical tissue. For this image frozen tissue sections were stained for immunofluorescence with specific antibodies to the apical junctional protein ZO1 (green), N. gonorrhoeae (red), and the nuclear dye DAPI (blue) (Photo courtesy of Dr. Liang-Chun Wang, Department of Cell biology and Molecular Genetics, University of Maryland).

Tissue Model Used to Show Molecular Basis for Infection

A team of molecular microbiologists has explained the mechanism by which Neisseria gonorrhoeae, the bacterium that causes the urinary tract infection gonorrhea, invades and colonizes female genital tissues. More...
27 Apr 2017
Image: Cardiomyocytes from patients with Duchenne muscular dystrophy (DMD) corrected by CRISPR-Cpf1 reframing during stemness (right) show restored dystrophin expression (red), compared to uncorrected cells (left) (Photo courtesy of Science Advances).

Modified CRISPR Gene Editing Technique Repairs Dystrophin Mutation

Researchers used an alternative form of the CRISPR/Cas9 genome editing system to correct a mutation in heart cells derived from Duchenne muscular dystrophy patient skin cells and in a mouse model of the disease. More...
26 Apr 2017
Image: Lipid nanoprobes (blue, green, and yellow colored) spontaneously insert themselves into lipid bilayer of three extracellular vesicles. The cargo content of extracellular vesicles includes proteins, DNA, and RNA. The lipid nanoprobe-labeled extracellular vesicles are captured onto the surface of a magnetic bead (black, bottom) through interaction with conjugated avidin molecules (red) (Photo courtesy of Xin Zou / Pennsylvania State University).

Lipid Nanoprobe Method Enables Rapid Isolation of Extracellular Vesicles

A novel method reduces the amount time required to isolate extracellular vesicles (EVs) from culture media or blood plasma from hours to 15 minutes and does not require bulky or expensive equipment. More...
25 Apr 2017
Image: Human stem cells derived from skin samples have been induced to form tiny, three-dimensional, brain-like cultures that behave similarly to cells in the human midbrain (Photo courtesy of the University of Luxembourg).

Novel Organoid Culture System Used for Brain Cell Research

Brain cells - derived from pluripotent stem cells - growing in culture assemble into three-dimensional (3D), brain-like structures (organoids) that can serve as an experimental model system for studies into the cellular biology of the normal and diseased brain. More...
24 Apr 2017
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BioResearch brings the latest research news on the genome, proteome, metabolome, on drug discovery, and therapeutics. Biotech researchers, lab administrators, technologists, drug manufacturers, and suppliers can find the latest research news and information related to their fields of endeavor here.

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