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BioResearch

Image: Cells with the Tpr protein (top row) have fewer nuclear pores than cells without the protein (bottom row). The right column shows a close-up of the pore density, with many more pores appearing in the absence of Tpr (bottom left) (Photo courtesy of the Salk Institute for Biological Studies).

Mechanism Identified for Control of Nuclear Pore Complexes

Researchers have identified a molecular mechanism that helps control the number of nuclear pore complexes in a cell, a measure of some importance, since cells that transform into cancers often have an excess of these features. More...
10 Oct 2018
Image: The structure of the recently developed cancer drug Metavert (Photo courtesy of the U.S. National Library of Medicine).

Candidate Cancer Drug Blocks Growth and Reverses Drug Resistance

A candidate drug for treatment of pancreatic cancer was shown to slow growth and spread of the disease in cell cultures and reverse drug resistance in preclinical animal models. More...
09 Oct 2018
Image: Very high magnification micrograph showing ragged red fibers (also ragged red fibers), commonly abbreviated RRF, in a mitochondrial myopathy (Photo courtesy of Wikimedia Commons).

Genome Editing Used to Correct Mitochondrial Mutations

A recently developed mouse model, which mimics a cardiac mitochondrial disease, was used to demonstrate the potential use of genomic engineering to treat the disorder by eliminating the mutation that causes it. More...
08 Oct 2018
Image: The humanin gene is found within the 16S rRNA gene (MT-RNR2) in the mitochondrial genome (Photo courtesy of Wikimedia Commons).

Mitochondrial Peptide Protects Brain from Age-Related Dementias

A recent study contributed new evidence that strengthens the hypothesis that the peptide humanin protects the brain against the development of Alzheimer's disease and other age-related dementias. More...
04 Oct 2018
Image: A micrograph of the most common type of renal cell carcinoma (clear cell)—on right of the image; non-tumor kidney is on the left of the image (Photo courtesy of Wikimedia Commons).

Nanoplatform Overcomes Kidney Cancer Drug Resistance

A team of cancer researchers reported the development of a novel "nanoplatform" technology that empowered existing chemotherapeutic drugs to overcome drug-resistance in Everolimus-resistant renal cell carcinoma. More...
03 Oct 2018
Image: Fluorescence images of pancreatic cancer microtumors following overnight culture. Papillary structures pile up on micro-attachment sites (diameter 30 micrometers), with numerous cells visible per patch. The rightmost microtumor has extended over two attachment sites. Nuclei, actin filaments, and microtubules are labeled with blue, green, and red fluorescent markers, respectively (Photo courtesy of Miyatake Y. et al., Scientific Reports, September 19, 2018).

In Vitro Technique Details Cancer Cell Attachment and Spread

A team of Japanese cell biologists described the development of a simple live-tumor in vitro imaging technique that enabled the study of the processes involved in the growth and spread of pancreatic cancer. More...
02 Oct 2018
Image: The natural antibiotic kanglemycin A binds bacterial RNA polymerase at the rifampicin binding-pocket, but maintains potency against rifampicin-resistant mutants due to two unique chemical groups (digitoxose and succinic acid) that increase its affinity to rifampicin-resistant RNA polymerase by binding just outside the rifampicin-binding pocket (Photo courtesy of the Murakami Laboratory, Pennsylvania State University).

Antibiotic Characterized for Drug-Resistant Strains of TB

An international team of biochemists and molecular biologists has isolated and characterized a novel, naturally occurring antibiotic that is capable of killing multidrug-resistant strains of Mycobacterium tuberculosis. More...
01 Oct 2018
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BioResearch brings the latest research news on the genome, proteome, metabolome, on drug discovery, and therapeutics. Biotech researchers, lab administrators, technologists, drug manufacturers, and suppliers can find the latest research news and information related to their fields of endeavor here.
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