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Pathology

Image: The Aperio AT2 is the ideal digital pathology slide scanner for high-throughput clinical laboratories, delivering precise eSlides with low rescan rate (Photo courtesy of Leica Biosystems).

Digital Pathology Solution Resolves the Tissue Floater Conundrum

In routine clinical practice, pathologists may encounter extraneous pieces of tissue on glass slides that could be because of contamination from other specimens. These are typically called tissue floaters. The dilemma pathologists often face is whether such a tissue floater truly belongs to the case in question, or if instead it represents a true contaminant from another patient’s sample in which case it should be ignored. More...
30 Jul 2020
Image: The benchtop SH800S cell sorter permits sorting of a wide range of cell sizes for many applications using the 70-μm, 100-μm, and 130-μm microfluidic sorting chips (Photo courtesy of Sony Biotechnology).

Pediatric Ependymoma Single-Cell Analysis Signatures Linked to Outcomes

An ependymoma is a tumor that arises from the ependyma, a tissue of the central nervous system. Usually, in pediatric cases the location is intracranial, while in adults it is spinal. The common location of intracranial ependymomas is the fourth ventricle. More...
30 Jul 2020
Image: FoundationOne liquid biopsy assays were used to study the association of circulating tumor DNA and circulating tumor cells after neoadjuvant chemotherapy with disease recurrence in patients with triple-negative breast cancer (Photo courtesy of Foundation Medicine).

Circulating Tumor DNA Associated with Triple-Negative Breast Cancer Recurrence

Patients with early-stage triple-negative breast cancer (TNBC) are frequently treated with neoadjuvant chemotherapy, based on the increased risk for recurrence and death associated with this category of tumors. More...
27 Jul 2020
Image: The RaDaR (Residual Disease and Recurrence) assay detects circulating tumor DNA (ctDNA) found in the bloodstream (Photo courtesy of Inivata).

CtDNA Assay for Cancer Recurrence, MRD Applications Demonstrated

Circulating tumor DNA (ctDNA) is found in the bloodstream and refers to DNA that comes from cancerous cells and tumors. Most DNA is inside a cell's nucleus. As a tumor grows, cells die and are replaced by new ones. The dead cells get broken down and their contents, including DNA, are released into the bloodstream. More...
22 Jul 2020
Image: A blue tumor organoid surrounded by red NK cells (Photo courtesy of Isaac Chan, MD, PhD).

Cancer Cells Reprogram Immune Cells to Assist in Metastasis

Natural killer (NK) cells, a type of immune cell, are known to limit metastasis by inducing the death of cancer cells, but metastases still form in patients, so there must be ways for cancer cells to escape. More...
20 Jul 2020
Image: Arrhythmic Gut Microbiome Signatures Predict Risk of Type 2 Diabetes (Photo courtesy of Technical University of Munich).

Type 2 Diabetes Associated with Arrhythmic Daily Gut Microbe

Type 2 diabetes (T2D), formerly known as adult-onset diabetes, is a form of diabetes that is characterized by high blood sugar, insulin resistance, and relative lack of insulin. Common symptoms include increased thirst, frequent urination, and unexplained weight loss. More...
16 Jul 2020
Image: The Oncotype DX Genomic Prostate Score (GPS) test is a strong independent predictor of prostate cancer-specific death and disease progression (metastases) at 10 years in men with localized prostate cancer (Photo courtesy of Genomic Health).

Gene Genomic Prostate Score Test Evaluated as Prognosis Predictor

Molecular assays, including multi-gene expression assays, are increasingly used clinically to improve risk stratification for men with newly diagnosed prostate cancer (PCa). More...
13 Jul 2020
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The Pathology channel details advances in the field of Surgical Pathology and all its subspecialties, including Cytopathology and its subspecialties.

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