We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress hp
Sign In
Advertise with Us
INTEGRA BIOSCIENCES AG

Download Mobile App




Protein Interactions Help Prevent Arterial Blockage

By LabMedica International staff writers
Posted on 17 Feb 2015
Print article
The protein alpha-1-microglobulin (A1M) helps to prevent development of arteriosclerosis by inhibiting the oxidation of LDL (low-density lipoproteins) that is induced by the combination of myeloperoxidase (MPO) and hydrogen peroxide.

MPO, a heme-containing enzyme that catalyzes the production of free radicals and hypochlorite, is released by neutrophils during the inflammatory response to bacterial infections. MPO-induced low-density lipoprotein (LDL)-oxidation in blood has been suggested as a causative factor in atherosclerosis. A1M, which binds and degrades heme, is a radical scavenger as well as a reductase. A model has been proposed in which A1M is described as a circulating “waste bin” which continuously removes free radicals and oxidizing agents, particularly heme, from the tissues. It is subsequently transported to the kidneys, where it is broken down. The protein is therefore believed to protect cells and tissues against the damage that is induced by abnormally high concentrations of free hemoglobin and/or reactive oxygen species.

Investigators at Lund University (Sweden) studied the interaction between A1M and MPO in an in vitro model system. They reported in the February 3, 2015, online edition of the journal Frontiers in Physiology that A1M was cleaved proteolytically, with formation of t-A1M, after exposure to MPO, and that t-A1M contained iron and heme-degradation products. The reaction was dependent on pH, time, and concentration of substrates and a pH-value around 7 was shown to be optimal for cleavage. Furthermore, A1M inhibited MPO- and hydrogen peroxide-induced oxidation of LDL.

Senior author Dr. Bo Akerstrom, professor of medicine at Lund University, said, "By studying and testing A1M's properties in relation to LDL and MPO, we discovered that A1M can clean and reduce oxidized blood fats from LDL, as well as taking care of the dangerous substances from MPO and breaking them down. This means that A1M protects against damage to the molecules that we know is a cause of atherosclerosis. The next step is animal experiments, as well as analysis of human tissues. We want to study the blood to see if there is a link between the level of A1M, the concentration of oxidized blood fats, and the development of atherosclerosis. If this correlation exists, which I believe it does, I can imagine that it will be possible in the future to develop a preventive drug that reduces the risk of atherosclerosis. It is not impossible that future patients could receive one dose of A1M per month to clean the blood vessels."

Related Links:

Lund University


New
Gold Member
Pneumocystis Jirovecii Detection Kit
Pneumocystis Jirovecii Real Time RT-PCR Kit
Antipsychotic TDM Assays
Saladax Antipsychotic Assays
New
Laboratory Electric Thermostat
DNP-9025A
New
Automated Cell Counter
QuadCount

Print article

Channels

Clinical Chemistry

view channel
Image: The new saliva-based test for heart failure measures two biomarkers in about 15 minutes (Photo courtesy of Trey Pittman)

POC Saliva Testing Device Predicts Heart Failure in 15 Minutes

Heart failure is a serious condition where the heart muscle is unable to pump sufficient oxygen-rich blood throughout the body. It ranks as a major cause of death globally and is particularly fatal for... Read more

Molecular Diagnostics

view channel
Image: The bowel cancer breakthrough could result in better treatment outcomes (Photo courtesy of 123RF)

New RNA Molecules Can Help Predict Bowel Cancer Return Recurrence

Colorectal cancer accounts for 10% of all cancer-related deaths worldwide and was ranked as the second most common cause of cancer death in the United States in 2022. Currently, clinicians face diagnostic... Read more

Hematology

view channel
Image: QScout CBC will give a complete blood count in 2 minutes from fingerstick or venous blood (Photo courtesy of Ad Astra Diagnostics)

Next Gen CBC and Sepsis Diagnostic System Targets Faster, Earlier, Easier Results

Every hour is critical in protecting patients from infections, yet there are currently limited tools to assist in early diagnosis before patients reach a hospital. The complete blood count (CBC) is a common... Read more

Microbiology

view channel
Image: The InfectoSynovia test has the potential to revolutionize the diagnosis of periprosthetic joint infection (Photo courtesy of 123RF)

High-Accuracy Bedside Test to Diagnose Periprosthetic Joint Infection in Five Minutes

Periprosthetic joint infection (PJI) represents a significant global issue that is worsening as the number of joint replacements increases due to aging populations. In the United States alone, the anticipated... Read more

Pathology

view channel
Image

AI-Based Method Shows Promise for Pathological Diagnosis of Hereditary Kidney Diseases

Alport syndrome is a hereditary kidney disorder characterized by kidney dysfunction, sensorineural hearing loss, and ocular abnormalities. Early in the disease, patients experience hematuria, which is... Read more
Copyright © 2000-2024 Globetech Media. All rights reserved.