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BioResearch

Image: The phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha (also called p110alpha protein) is a class I PI 3-kinase catalytic subunit. The human p110alpha protein is encoded by the PIK3CA gene (Photo courtesy of Wikimedia Commons).

Inhibiting Glutamine Metabolism Blocks Growth of Some Colorectal Tumors

Cancer researchers have found a way to block growth of colorectal tumors that express a mutation, which enables the cancer cells to use glutamine as their primary energy source. More...
01 Aug 2016
Image: A team of scientists has discovered an organic ‘smart’ biodegradable nanoparticle, named PEARL, that uses light and heat in a controlled manner to target and destroy tumors with bigger precision (Photo courtesy of the University Health Network).

Smart Nanoparticles Deliver Selective Heating to Kill Tumors

Cancer researchers have demonstrated a novel type of "smart" nanoparticle that can destroy a tumor through selective heating while causing minimal damage to surrounding normal tissues. More...
28 Jul 2016
Image: An atomic-level structural model of coxsackievirus B3 polymerase, which is responsible for making copies of the virus genome. The researchers replaced the orange phenylalanine 364 that is found in two different positions, with the turquoise tryptophan that is larger and covers both positions without needing to move. This causes fewer mutations to be made and reduces the ability of the virus to replicate and cause disease (Photo courtesy of Dr. Olve Peersen, Colorado State University).

RNA Polymerase Mutation Stabilizes Live Virus Vaccines

A team of molecular virologists has developed a more effective method for attenuating the replicative capabilities of the coxsackievirus and is using this platform to develop a vaccine for it and other positive-sense single-stranded RNA viruses, a group that includes poliovirus, dengue, and Zika. More...
28 Jul 2016
Image: Fungi can be stimulated with distinct substances for production of antibiotic metabolic products (Photo courtesy of BiMM Research).

Fungi Exposed to Valproic Acid Produce Substances with Potential Antibiotic Properties

Drug developers have used valproic acid (VPA) to coax various types of fungi to produce "cryptic" bioactive molecules, some of which have potential as antibiotic agents. More...
27 Jul 2016
Image: Cells labeled to identify proteins that regulate the expression of a genetic switch for T-cells. On the right, T-cells where the switch is activated glow in yellow. On the left, the rainbow pattern, a hierarchical cluster analysis, tells investigators which genes are controlled by the switch. The horizontal stripes are the genes. If they stripes turn red going from left to right, it means they are turning on; if they turn blue, the genes are turning off (Photo courtesy of the California Institute of Technology).

Multitiered Molecular Control Mechanism Regulates T-cell Genetic Switch

Three distinct molecular processes act in a stage-specific manner to provide a multitiered system for regulating the T-cell developmental gene BCL11B (B-cell CLL/Lymphoma 11B). More...
27 Jul 2016
Image: Mitochondrial DNA (green spots) is found at points where mitochondria (blue) are in contact with the endoplasmic reticulum (red) (Photo courtesy of Dr. Samantha Lewis, University of California, Davis).

Mitochondrial Replication Mechanism Identified

The mechanism that controls division of mitochondria and replication of mitochondrial DNA (mtDNA) during the process of mitosis has been shown to be localized at sites where the mitochondria are in contact with the endoplasmic reticulum (ER). More...
26 Jul 2016
Image: A photomicrograph of Toxoplasma gondii tachyzoites, stained with Giemsa (Photo courtesy of the CDC).

New Model Boosts Development of Drugs to Treat Toxoplasmosis

A novel model system to facilitate development of drugs to treat toxoplasmosis and other parasitic infections is based on a strain of Toxoplasma gondii that produces cysts in vitro that mimic those found in living animals. More...
26 Jul 2016
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BioResearch brings the latest research news on the genome, proteome, metabolome, on drug discovery, and therapeutics. Biotech researchers, lab administrators, technologists, drug manufacturers, and suppliers can find the latest research news and information related to their fields of endeavor here.

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