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Pathology

Image: Schematic diagram of the IMMray PanCan-d assay that relies on the IMMray microarray technology, where single chain fragment antibodies are printed onto a slide in a measured amount as a microarray of different antibody biomarkers (Photo courtesy of Immunovia)

Immunoassay Detects Pancreatic Cancer in People at High Risk

An immunoassay was able to detect pancreatic cancer in high-risk individuals and with high sensitivity and specificity. More...
28 Feb 2022
Image: Oxford BioDynamics Plc has announced the successful clinical validation and US launch of its Checkpoint Inhibitor Response Test (Photo courtesy of Oxford BioDynamics)

First-of-Its-Kind Clinical Blood Test Predicts Cancer Patient’s Response to ICI Immunotherapy

A first-of-its-kind clinical blood test predicts the likelihood of a cancer patient’s response to an essential, widely used class of therapeutics – Immune Checkpoint Inhibitors (ICIs) – including anti-PD-L1 and anti-PD-1 immunotherapies. More...
28 Feb 2022
Image: Histopathology of dilated cardiomyopathy of unknown etiology in a 58 year female. The histologic findings in dilated cardiomyopathy are usually nonspecific. The image shows myocyte hypertrophy with enlarged hyperchromatic nuclei, mixed with myocyte atrophy and stretching. In addition, there is focal interstitial fibrosis (Photo courtesy of Dr. Dharam Ramnani)

Tintin-Truncating Variant Associated With Late-Onset Dilated Cardiomyopathy

Late-onset dilated cardiomyopathy might represent a distinct disease subtype marked by an increased burden of genetic variants, a new study has found. The findings further suggested that genetic testing may be beneficial for older dilated cardiomyopathy patients. More...
21 Feb 2022
Image: Highly atypical cells in marrow examined for large cell transformation. Bone marrow core biopsies demonstrating (A) highly atypical cells including cells with prominent spindling of the nucleus and (B) cells with marked pleomorphism and/or multinucleation (Photo courtesy of Yale Medicine)

Histological Criteria Predicts Lymphoma Transformation in Bone Marrow Biopsies

Large cell transformation (LCT) of indolent B-cell lymphomas, such as follicular lymphoma (FL) and chronic lymphocytic leukemia (CLL), signals a worse prognosis, at which point aggressive chemotherapy is initiated. Although LCT is relatively straightforward to diagnose in lymph nodes, a marrow biopsy is often obtained first given its ease of procedure, low cost, and low morbidity. However, consensus criteria for LCT in bone marrow have not been established. More...
16 Feb 2022
Image: Galleri Multi-Cancer Test (Photo courtesy of GRAIL, LLC)

Multi-Cancer Early Detection Test Could Become a Game-Changing Screening Tool

A first-of-kind multi-cancer early detection test can detect over 50 types of cancers with a low false positive rate through a single blood draw. More...
16 Feb 2022
Image: TriNetra-Prostate blood test (Photo courtesy of Datar Cancer Genetics)

Early-Stage Prostate Cancer Detection Blood Test Granted FDA Breakthrough Designation

A circulating tumor cell (CTC) detection blood test can identify early-stage prostate cancer with high accuracy in men of age 55-69 years. More...
16 Feb 2022
Image: Immunochemistry showing strong immunoreactivity for p53 in Barrett\'s esophagus with high-grade dysplasia (Photo courtesy of ARP Press (@ARP_Press)

Cytosponge Biomarker Panel Prioritizes Endoscopic Barrett's Esophagus Surveillance

Endoscopic surveillance is recommended for patients with Barrett's esophagus because, although the progression risk is low, endoscopic intervention is highly effective for high-grade dysplasia and cancer. However, repeated endoscopy has associated harms and access has been limited during the COVID-19 pandemic. We aimed to evaluate the role of a non-endoscopic device (Cytosponge) coupled with laboratory biomarkers and clinical factors to prioritize endoscopy for Barrett's esophagus. More...
15 Feb 2022
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The Pathology channel details advances in the field of Surgical Pathology and all its subspecialties, including Cytopathology and its subspecialties.

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