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Pathology

Image: The HiSeq 2500 System is a powerful high-throughput sequencing system (Photo courtesy of Illumina).

Colorectal Cancer Risk Linked to Common and Rare Variants

Colorectal cancer (CRC), also known as bowel cancer and colon cancer, is the development of cancer from the colon or rectum (parts of the large intestine). Screening, by one of a number of methods, is recommended starting from the age of 50 to 75. More...
20 Dec 2018
Image: Patients with inflammatory bowel disease who have an elevated PSA, may be at risk for prostate cancer (Photo courtesy of Harvard University).

Inflammatory Bowel Disease Linked to Prostate Cancer

About one million men have inflammatory bowel disease in the USA, a common chronic condition that includes Crohn's disease and ulcerative colitis. Epidemiologic studies have noted an association between chronic inflammation and prostate cancer. More...
18 Dec 2018
Image: The Rapid Amplification of ctDNA Ends (RACE) next-generation sequencing (NGS) assay (Photo courtesy of ArcherDx).

Liquid Biopsy Identifies Advanced Lung Cancer Drivers

Liquid biopsy for plasma circulating tumor DNA (ctDNA) next-generation sequencing (NGS) is commercially available and increasingly adopted in clinical practice despite a paucity of prospective data to support its use. More...
13 Dec 2018
Image: A malignant melanoma of the skin (Photo courtesy of Juan Gaertner).

Circulating Tumor DNA Detects Early Melanoma Growth

According to the National Cancer Institute, there were 91,270 new cases of melanoma in 2018, making up more than 5% of all new cancer cases. There were 9,320 estimated deaths in 2018, and 91.8% of patients survive five years or longer. More...
11 Dec 2018
Image: A diagram of the basis of the IvyGene Methylation-Based Liquid Biopsy Test to detect cancer (Photo courtesy of Dr. Kevin Conners).

Methylation-Based Liquid Biopsy Test Detects Liver Cancer

Hepatocellular carcinoma (HCC) represents about 75% of liver cancers in the USA and already has well-established screening criteria focused largely on individuals with cirrhosis, who are screened every six months using ultrasound with or without blood testing for alpha- fetoprotein, according to guidelines. More...
06 Dec 2018
Image: The CellSearch Platform for identification, isolation, and enumeration of circulating tumor cells (Photo courtesy of Menarini Silicon Biosystems).

Liquid Biopsy Detects Cancer across Multiple Biomarkers

Although biomarker-directed therapy is in its infancy in prostate cancer compared to some other tumor types, there is a great need for predictive biomarker testing, and great interest in noninvasive methods. However, comprehensive analysis of patients' cell-free DNA has been limited to date. More...
06 Dec 2018
Image: The NextSeq 550 System delivers the power of high-throughput sequencing with the speed, simplicity, and affordability of a benchtop next-generation sequencing (NGS) system (Photo courtesy of Illumina).

Genes Identified That Predispose People to Chronic Kidney Disease

Chronic kidney disease (CKD) affects 10% to 15% of the population worldwide and is now recognized as the most rapidly increasing contributor to global burden of disease. The costs related to CKD and end-stage renal disease (the terminal manifestation of CKD) are an enormous burden for all healthcare systems around the world. More...
05 Dec 2018
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The Pathology channel details advances in the field of Surgical Pathology and all its subspecialties, including Cytopathology and its subspecialties.

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