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BioResearch

Image: The illustration depicts glucose-responsive exendin-4 delivery via microneedle patch. At left, relatively lower glucose levels (turquoise) in blood induce a mild chemical reaction with the compounds in the patch, which is not sufficient to release exendin-4. At right, when blood glucose concentration rises, acidity in blood triggers rapid release of exendin-4 (pink) for blood glucose regulation. The result is a smart, long-acting and on-demand exendin-4 release (Photo courtesy of the Chen laboratory, National Institute of Biomedical Imaging and Bioengineering).

Smart Release Skin Patch Corrects Type II Diabetes in Model

A novel approach for treating type II diabetes is based on microneedle-array patches that are loaded with dual mineralized protein/peptide particles that release the hormone exendin-4 in response to elevated blood sugar levels. More...
10 Jan 2018
Image: Probes revealed the inner architecture when the A2AAR protein transmitted molecular signals through a cell membrane (Photo courtesy of Drs. Kurt Wüthrich and Matthew Eddy, The Scripps Research Institute).

Single Amino Acid Controls Signaling Molecule Activity

An advanced NMR (nuclear magnetic resonance) spectroscopy technique was used to follow the dynamic structural changes that occurred during binding of a drug to a cell membrane-spanning G protein-coupled receptor. More...
09 Jan 2018
Image: A three-dimensional hydrogel construct fabricated through drop-on-drop multi-material bio-printing (Photo courtesy of Osaka University).

Cross-linked Hydrogels Developed for 3D Printing

A team of Japanese biomedical engineers has developed a novel, enzyme-based three-dimensional printing method that enables in vitro growth of complex cellular structures. More...
08 Jan 2018

Genomic Study Links Potassium Levels to Regulation of BP

A recent paper described a study designed to examine different points of the human genome to determine where the genetic sequence linked serum potassium levels to modulation of blood pressure (BP). More...
04 Jan 2018
Image: Skeletal muscle cells isolated using the ERBB3 and NGFR surface markers (right) restore human dystrophin (green) after transplantation significantly greater than previous methods (left) (Photo courtesy of the University of California, Los Angeles and Nature Cell Biology).

Combined Treatments Cure Muscular Dystrophy in Model

A new approach for generating functional muscle tissue from induced human pluripotent stem cells enabled replacement of muscle loss in a mouse model of Duchenne muscular dystrophy (DMD). More...
03 Jan 2018
Image: A molecular dynamics model showing a nanoparticle binding to the outer envelope of the human papillomavirus (Photo courtesy of Dr. Petr Kral, Ecole Polytechnique Fédérale de Lausanne).

Novel Nanoparticles May Lead to Universal Antiviral Drug

A team of molecular virologists has developed a nanoparticle-based broad-spectrum antiviral agent that binds irreversibly to a large range of viruses and causes lethal structural deformations without affecting healthy tissue. More...
02 Jan 2018
Image: An adeno-associated virus (AAV) was used to transport genes for CRISPR/Cas9 into motor neurons to delay onset of symptoms of ALS in mice (Photo courtesy of Dr. David Schaffer, University of California, Berkeley).

CRISPR/Cas9 Treatment Eases Symptoms in ALS Model

Neurodegenerative disease researchers treated a mouse model of amyotrophic lateral sclerosis with a modified adeno-associated virus that delivered the CRISPR/Cas9 gene-editing tool to the animals' neurons, where it disabled a malfunctioning gene. More...
01 Jan 2018
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BioResearch brings the latest research news on the genome, proteome, metabolome, on drug discovery, and therapeutics. Biotech researchers, lab administrators, technologists, drug manufacturers, and suppliers can find the latest research news and information related to their fields of endeavor here.

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