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BioResearch

Image: A mouse breast tumor that contains bone marrow-derived fibroblasts (red) as well as other cancer-associated fibroblasts (green) (Photo courtesy of Raz et al., 2018).

Subpopulation of Fibroblasts Drives Breast Tumor Development

Breast tumors with reduced levels of the enzyme platelet-derived growth factor alpha (PDGFRalpha), which is caused by recruitment of a distinct subpopulation of bone marrow-derived cancer-associated fibroblasts, have been linked to a worse prognosis for the patient. More...
03 Dec 2018
Image: Two components of Mallotus leaf extract bind to a previously unrecognized binding site on KCNQ1, a potassium channel essential for controlling electrical activity in many human organs. The image shows a computer model illustrating the novel herbal component, CPT1, an isovaleric acid molecule (green), occupying a novel binding site (R243, red) to activate KCNQ1 (Photo courtesy of Dr. Geoffrey Abbott, University of California, Irvine School of Medicine).

African Folk Drug Modulates Critical Potassium Channel Protein

A leaf extract used for hundreds of years in African folk medicine was shown to act by influencing the behavior of a protein that forms a critical potassium channel found in many human organs. More...
29 Nov 2018
Image: The method for assembly of protein nanotubes involved a four-step process: 1) introduction of cysteine residues into the wild-type protein; 2) crystallization of the engineered protein into a lattice structure; 3) formation of a cross-linked crystal; and 4) dissolution of the scaffold to release the protein nanotubes (Photo courtesy of Chemical Science).

Protein Crystals Used to Prepare Cellular Drug Delivery Nanotubes

A team of Japanese biomolecular engineers used scaffolds of cross-linked protein crystals to prepare nanotubes, which are structures that can serve as the basis for minute delivery systems for drugs and other substances. More...
28 Nov 2018
Image: Researchers developed a technique to prepare polyol-modified nanoparticles that could locate cancerous cells and tumors via the blood vessels surrounding the tumors (Photo courtesy of Purdue University).

Modified Nanoparticle Drug Carriers Target Solid Tumors in Model

Cancer researchers used novel targeted nanoparticles to transport drugs to solid tumors when the absence of a persistent EPR (enhanced permeability and retention) effect, acted as an access barrier negatively affected the effectiveness of drug delivery. More...
27 Nov 2018
Image: A photomicrograph of a kidney organoid showing neurons in red and kidney cells in green (Photo courtesy of Humphreys Laboratory, Washington University).

New Method Eliminates Unwanted Neurons from Cultures of Kidney Organoids

A method has been reported that is able to eliminate more than 90% of unwanted neurons from cultures of stem cell-generated kidney cell organoids. More...
26 Nov 2018
Image: A transmission electron microscopic (TEM) image of influenza A virions in late passage growth phase (Photo courtesy of the CDC).

Linked Antibodies Provide Universal Protection from Influenza Infection

A potential universal vaccine that would protect individuals from infection by all strains of influenza virus is based on multidomain antibodies that were fabricated by combining selected llama single-domain antibodies. More...
22 Nov 2018
Image: A scanning electron micrograph (SEM) of a human T-cell (Photo courtesy of the U.S. National Institutes of Health).

Technology Evaluated for T-cell Receptor Identification and Cloning

A team of cancer researchers developed a tracking and screening system that accurately identifies T-cell receptors from individual tumors within just a few days. More...
21 Nov 2018
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BioResearch brings the latest research news on the genome, proteome, metabolome, on drug discovery, and therapeutics. Biotech researchers, lab administrators, technologists, drug manufacturers, and suppliers can find the latest research news and information related to their fields of endeavor here.
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