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Pathology

Image: The Z2 Coulter Counter Analyzer can be used to analyze virtually any cell type and species variation (Photo courtesy of Beckman Coulter).

Biomarker Predicts Pancreatic Cancer Patients’ Response to CD40 Immunotherapy

Pancreatic ductal adenocarcinoma (PDAC) is the most common type of pancreatic cancer and currently the third leading cause of cancer deaths in the USA. Despite the fact that it only accounts for about 3% of new cancer cases, it is responsible for more than 7% of all cancer deaths, and only10% of patients survive five years with the disease. More...
17 Feb 2021
Image: The Anyplex II HPV28 Detection Kit simultaneously detects and identifies 28 HPV types (19 high-risk and 9 low-risk) (Photo courtesy of Seegene).

TAP1 Gene Polymorphisms Associated with Recurrent Respiratory Papillomatosis

Recurrent respiratory papillomatosis (RRP) is a respiratory tract disease that affects children and adults and is characterized by the recurrent proliferation of multiple papillomas. The proliferation of multiple papillomas within the airway in RRP primarily affects the larynx. More...
09 Feb 2021
Image: Photomicrograph of a moderately differentiated colorectal carcinoma with dirty necrosis (Photo courtesy of Mikael Häggström, MD).

Blood Test Detects Early Colorectal Adenomas

Colonoscopies are the gold standard for screening but have low compliance rates due to the invasiveness of the procedure. Stool-based tests have poor compliance and low sensitivity for advanced adenomas (AA), at about 24% to 42%. More...
08 Feb 2021
Image: The Natera Signatera Assay Can Predict Colon Cancer Relapse Months Earlier (Photo courtesy of Mohammed Haneefa Nizamud)

Liquid Biopsy Predicts Colon Cancer Relapse Months Earlier

Colorectal cancer (CRC), also known as bowel cancer, colon cancer, or rectal cancer, is the development of cancer from the colon or rectum (parts of the large intestine). Signs and symptoms may include blood in the stool, a change in bowel movements, weight loss, and fatigue. More...
03 Feb 2021
Image: DNA fragments (yellow) derived from a transplanted heart alongside the patient’s own DNA (blue). A new blood test measures donor DNA fragments and detects acute heart transplant rejection earlier than current methods (Photo courtesy of Erina He, NIH Medical Arts)

Cell-Free DNA Detects Heart Allograft Acute Rejection

After heart transplantation, Endomyocardial biopsy (EMBx) is used to monitor for acute rejection (AR). Unfortunately, EMBx is invasive and its conventional histologic interpretation has limitations. More...
02 Feb 2021
Image: The MACSQuant Analyzer 10 flow cytometer has three lasers (405, 488, 638 nm), two scatter (FSC, SSC) and seven fluorescent channels (Photo courtesy of Miltenyi Biotec)

Proinflammatory T Cell Polarization Investigated in Early Knee Osteoarthritis

In osteoarthritis (OA), the cartilage in the knee joint gradually wears away. As the cartilage wears away, it becomes frayed and rough, and the protective space between the bones decreases. This can result in bone rubbing on bone, and produce painful bone spurs. Osteoarthritis develops slowly and the pain it causes worsens over time. More...
01 Feb 2021
Image: The Simoa HD-X fully automated immunoassay platform with multiplexing and custom assay capability (Photo courtesy of Quanterix Corporation).

Alzheimer's Progression Tracked with Blood Biomarkers

Alzheimer disease (AD) is a neurodegenerative disorder characterized by the accumulation of amyloid-β (Aβ) plaques and neurofibrillary tangles of hyperphosphorylated tau in the brain. These neuropathological changes are believed to take part in a cascade of events that result in a characteristic neurodegeneration pattern followed by progressive cognitive impairment. More...
28 Jan 2021
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The Pathology channel details advances in the field of Surgical Pathology and all its subspecialties, including Cytopathology and its subspecialties.

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